Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychodynamic Perspectives on Personality01:27

Psychodynamic Perspectives on Personality

1.6K
The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
Psychodynamic theorists argue that unconscious...
1.6K
Social Cognitive Perspective on Personality01:30

Social Cognitive Perspective on Personality

1.0K
Social cognitive perspectives on personality emphasize the importance of conscious awareness, beliefs, expectations, and goals in shaping behavior. These perspectives incorporate behaviorist principles, such as learning through reinforcement and conditioning, but extend beyond them by highlighting human reasoning and planning. Unlike traditional behaviorist views, social cognitive theory focuses on how individuals reflect on their past experiences and plan for future outcomes by considering...
1.0K
Criticisms of the Evolutionary Perspective01:23

Criticisms of the Evolutionary Perspective

375
In a study where individuals posing as strangers offered compliments and proposed casual sex to students, the responses differed significantly based on gender. Not a single woman accepted the proposal, while 70% of the men agreed. This outcome provides a useful scenario to explore through the lens of evolutionary psychology and social learning theory, highlighting the diverse perspectives on human sexual behaviors.
Evolutionary psychology provides one explanation for these findings, suggesting...
375
The Behavioral Perspective on Personality01:19

The Behavioral Perspective on Personality

818
Behaviorists view personality as primarily shaped by environmental reinforcements and consequences. According to this perspective, behavior is influenced by external stimuli, and individuals adjust their actions based on rewards and punishments. Over time, learning histories — accumulated patterns of reinforcement — play a significant role in shaping personality. Behaviors that lead to positive outcomes are reinforced, while those resulting in negative outcomes are diminished.
818
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

86.6K
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
86.6K
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

3.5K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structures of the PI3Kα/KRas complex on lipid bilayers reveal molecular mechanisms of PI3Kα activation.

Molecular cell·2026
Same author

pH-Responsive peptide nanopores are stabilized by lipid and water-mediated hydrogen bonding networks.

Nanoscale·2026
Same author

CNPY4 is a Lipid-Binding Regulator of Sphingolipid Homeostasis.

bioRxiv : the preprint server for biology·2025
Same author

Structures of the PI3Kα/KRas complex on lipid bilayers reveal the molecular mechanism of PI3Kα activation.

bioRxiv : the preprint server for biology·2025
Same author

Structural basis for the transmembrane signaling and antidepressant-induced activation of the receptor tyrosine kinase TrkB.

Nature communications·2024
Same author

Structural Determinants of Peptide Nanopore Formation.

ACS nano·2024

Related Experiment Video

Updated: Jan 31, 2026

mRNA Interactome Capture from Plant Protoplasts
12:29

mRNA Interactome Capture from Plant Protoplasts

Published on: July 28, 2017

9.6K

The RTK Interactome: Overview and Perspective on RTK Heterointeractions.

Michael D Paul1, Kalina Hristova1

  • 1Department of Materials Science and Engineering, Institute for NanoBioTechnology, and Program in Molecular Biophysics , Johns Hopkins University , Baltimore , Maryland 21218 , United States.

Chemical Reviews
|December 28, 2018
PubMed
Summary

Receptor tyrosine kinases (RTKs) form complex networks, or interactomes, influencing cell signaling. Understanding RTK interactions and thermodynamics is crucial for deciphering cellular processes and improving therapeutic strategies.

More Related Videos

Perspectives on Neuroscience
26:41

Perspectives on Neuroscience

Published on: July 31, 2007

5.3K
Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing
12:04

Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing

Published on: October 3, 2018

9.4K

Related Experiment Videos

Last Updated: Jan 31, 2026

mRNA Interactome Capture from Plant Protoplasts
12:29

mRNA Interactome Capture from Plant Protoplasts

Published on: July 28, 2017

9.6K
Perspectives on Neuroscience
26:41

Perspectives on Neuroscience

Published on: July 31, 2007

5.3K
Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing
12:04

Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing

Published on: October 3, 2018

9.4K

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Receptor tyrosine kinases (RTKs) are key regulators of cell growth, motility, differentiation, and survival.
  • RTKs are typically activated by ligand binding, leading to homodimerization and autophosphorylation.
  • However, RTK interactions are complex, involving ligand-independent interactions and heterodimerization within and across subfamilies.

Purpose of the Study:

  • To review known cross-subfamily RTK heterointeractions and their biological implications.
  • To discuss methodologies for studying RTK interactions.
  • To explore the utility of thermodynamic models in understanding RTK behavior and complex signaling effects.

Main Methods:

  • Literature review of RTK cross-subfamily heterointeractions.
  • Discussion of methodologies used to study these interactions.
  • Application of thermodynamic models to explain observed biological effects.

Main Results:

  • RTKs exhibit complex interactions beyond simple ligand-induced homodimerization, including ligand-independent interactions and heterodimerization.
  • Thermodynamic models can explain intricate biological effects associated with RTK signaling.
  • The concept of an extensive RTK interactome, a network of RTK interactions, is proposed.

Conclusions:

  • The RTK interactome can generate unique signaling outputs, modulate signaling pathways, and provide signaling backups.
  • Understanding RTK interactome thermodynamics is essential for comprehending fundamental RTK signaling in health and disease.
  • Quantitative, thermodynamic studies are needed to elucidate the strengths of RTK-ligand and RTK-RTK interactions.