Imaging of Moyamoya Disease and Moyamoya Syndrome: Current Status
Jincheng Li, Meiyu Jin1, Xiaoyan Sun
1Jilin People's Hospital, Changchun, Jilin.
Abstract:
Moyamoya disease (MMD) and Moyamoya syndrome (MMS) are referring to a progressive steno-occlusive vasculopathy at terminal portions of the bilateral internal carotid arteries and their proximal branches with prominent collateral artery formation. They can be found throughout the world and cause irreversible damage to the cerebral hemodynamics due to the progressive nature. Prompt diagnosis and accurate assessment could significantly improve the prognosis of MMD and MMS. Some imaging modalities could be used for diagnosis and nonquantitative evaluation of MMD and MMS, such as conventional computed tomography (CT) and magnetic resonance imaging (MRI), digital subtraction angiography, CT angiography (CTA), and magnetic resonance angiography. Some could quantitatively evaluate the cerebral hemodynamics of MMD and MMS, such as single-photon emission CT, positron emission tomography, xenon-enhanced CT, perfusion CT, dynamic susceptibility contrast MRI, arterial spin labeling MRI, and the hemodynamic parameters measured by those imaging methods could guide treatment of MMD and MMS. All the imaging modalities have their merits and demerits, and they can play a part in certain situation. We need establish standardized protocols for preoperative and postoperative evaluation with different imaging techniques in the further science for MMD and MMS.
Insights
Moyamoya disease (MMD) and Moyamoya syndrome (MMS) involve progressive artery narrowing in the brain. Early diagnosis using various imaging techniques is crucial for better patient outcomes and guiding treatment decisions.
Area of Science:
- Neurology
- Radiology
- Vascular Medicine
Background:
- Moyamoya disease (MMD) and Moyamoya syndrome (MMS) are characterized by progressive steno-occlusive vasculopathy affecting major cerebral arteries.
- This condition leads to irreversible cerebral hemodynamic damage due to its progressive nature.
Purpose of the Study:
- To review diagnostic and quantitative imaging modalities for Moyamoya disease and Moyamoya syndrome.
- To highlight the importance of prompt diagnosis and accurate assessment for improving patient prognosis.
Main Methods:
- Conventional imaging: CT, MRI, digital subtraction angiography, CTA, MRA for diagnosis and nonquantitative evaluation.
- Quantitative imaging: SPECT, PET, Xenon-enhanced CT, perfusion CT, DSC-MRI, ASL-MRI for hemodynamic assessment.
Main Results:
- Various imaging modalities offer different capabilities for diagnosing and evaluating MMD and MMS.
- Quantitative imaging provides hemodynamic parameters that can guide treatment strategies.
Conclusions:
- Accurate assessment of MMD and MMS using imaging is vital for prognosis.
- Standardized protocols for preoperative and postoperative evaluation with different imaging techniques are needed for future research.
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