Imaging of Moyamoya Disease and Moyamoya Syndrome: Current Status

Jincheng Li, Meiyu Jin1, Xiaoyan Sun

  • 1Jilin People's Hospital, Changchun, Jilin.

Insights

Moyamoya disease (MMD) and Moyamoya syndrome (MMS) involve progressive artery narrowing in the brain. Early diagnosis using various imaging techniques is crucial for better patient outcomes and guiding treatment decisions.

Area of Science:

  • Neurology
  • Radiology
  • Vascular Medicine

Background:

  • Moyamoya disease (MMD) and Moyamoya syndrome (MMS) are characterized by progressive steno-occlusive vasculopathy affecting major cerebral arteries.
  • This condition leads to irreversible cerebral hemodynamic damage due to its progressive nature.

Purpose of the Study:

  • To review diagnostic and quantitative imaging modalities for Moyamoya disease and Moyamoya syndrome.
  • To highlight the importance of prompt diagnosis and accurate assessment for improving patient prognosis.

Main Methods:

  • Conventional imaging: CT, MRI, digital subtraction angiography, CTA, MRA for diagnosis and nonquantitative evaluation.
  • Quantitative imaging: SPECT, PET, Xenon-enhanced CT, perfusion CT, DSC-MRI, ASL-MRI for hemodynamic assessment.

Main Results:

  • Various imaging modalities offer different capabilities for diagnosing and evaluating MMD and MMS.
  • Quantitative imaging provides hemodynamic parameters that can guide treatment strategies.

Conclusions:

  • Accurate assessment of MMD and MMS using imaging is vital for prognosis.
  • Standardized protocols for preoperative and postoperative evaluation with different imaging techniques are needed for future research.

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