Porcine Acellular Peritoneal Matrix in Immediate Breast Reconstruction: A Multicenter, Prospective, Single-Arm Trial

Area of Science:

• Plastic Surgery
• Biomaterials Science
• Regenerative Medicine

Background:

• Acellular dermal matrices (ADMs) are commonly used in tissue expander breast reconstruction.
• Prospective studies on ADMs are limited.
• This study evaluates a novel porcine-derived acellular peritoneal matrix (APM) for immediate breast reconstruction.

Purpose of the Study:

• To assess the safety and outcomes of a porcine-derived APM in immediate tissue expander-based breast reconstruction.
• To analyze complications, histological characteristics, and patient satisfaction.

Main Methods:

• A prospective, single-arm trial involving 25 patients (44 breasts).
• Utilized a porcine-derived APM surgical mesh implant with tissue expanders.
• Evaluated patient demographics, surgical data, complications, histology, and BREAST-Q satisfaction scores.

Main Results:

• Sixteen breasts (36%) experienced complications, including wound dehiscence (9.1%).
• Reconstruction failure occurred in 6.8% of subjects, preceded by wound dehiscence.
• Histology confirmed cellular infiltration and resorption; patient satisfaction was comparable to existing literature.

Conclusions:

• Porcine-derived APM is a safe adjunct for immediate two-stage tissue expander breast reconstruction.
• Further studies are necessary to establish its efficacy relative to other commercially available ADMs.