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Updated: Jan 31, 2026

Clinical Application of 24 G Cannula Needle and 3-0 Polypropylene Suture in Vas Deferens Exploration
Published on: February 10, 2023
Arterial Wall Penetration Forces in Needles versus Cannulas
Tatjana Pavicic1, Katherine L Webb1, Konstantin Frank1
1From private practice and the Department for Hand, Plastic and Aesthetic Surgery, Ludwig Maximilian University; the Department of Medical Education, Albany Medical College; private practice; and Medical School General Hospital, University of Sao Paulo.
Facial soft-tissue filler injections: Larger cannulas (22- and 25-gauge) require more force to penetrate arteries than needles, indicating increased safety. However, 27-gauge cannulas offer no significant safety advantage over needles.
Area of Science:
- Dermatology and Aesthetic Medicine
- Medical Device Safety
- Anatomical Research
Background:
- Facial soft-tissue filler injections carry risks of arterial penetration.
- Cannulas are proposed as a safer alternative to needles for filler injections.
- Assessing the safety of different cannulas versus needles is crucial for minimizing vascular complications.
Purpose of the Study:
- To compare the safety of various-sized cannulas against correspondingly sized needles for facial soft-tissue filler application.
- To determine if cannulas offer a reduced risk of facial artery penetration compared to needles.
Main Methods:
- Penetration force testing was conducted on facial and superficial temporal arteries in four fresh frozen cephalic specimens.
- Needles (20-, 22-, 25-, 27-gauge) and cannulas (22-, 25-, 27-gauge) were used in 294 penetration procedures.
- Force required for intraarterial penetration was continuously measured.
Main Results:
- Penetration force decreased significantly with smaller gauge needles and cannulas.
- 22- and 25-gauge cannulas required significantly greater force for arterial penetration compared to needles of the same size.
- No significant difference in penetration force was observed between 27-gauge needles and 27-gauge cannulas.
Conclusions:
- 22- and 25-gauge cannulas are safer than correspondingly sized needles for facial filler injections due to higher penetration force requirements.
- 27-gauge cannulas do not offer a safety advantage over 27-gauge needles in terms of arterial penetration force.
- Cannula size is a critical factor in determining safety during facial filler procedures.
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