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Polysaccharides such as glycogen and starch are synthesized from nucleoside diphosphate sugars, primarily uridine diphosphate glucose (UDPG) and adenosine diphosphate glucose (ADPG). These activated glucose donors act as key intermediates in carbohydrate metabolism and biosynthesis. UDPG primarily involves glycogen synthesis in animals and many bacteria, while ADPG plays a fundamental role in starch synthesis in plants and certain bacteria.UDPG is formed when glucose-1-phosphate reacts with...
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According to its composition, the matter can be classified into two broad categories — pure substances and mixtures. 
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Polyprotic acids of the type H2M constitute two ionizable protons. As a result, on titration with a base, they exhibit two equivalence points in the titration curve. During titration, the species H2M, HM−, and M2− will be present in the solution at different points. The fractions of H2M, HM−, and M2− present at the various instances of the titration are denoted by α0, α1, and α2, respectively.
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The human body is composed of cells that are fundamentally made up of several different molecules. These molecules are essential to carry out all physiological processes in the body and are broadly classified into organic and inorganic based on their chemical structures.
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Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
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Compound polysaccharides ameliorate experimental colitis by modulating gut microbiota composition and function.

Ying Cai1, Wen Liu1, Yixuan Lin2

  • 1School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, China.

Journal of Gastroenterology and Hepatology
|December 28, 2018
PubMed
Summary
This summary is machine-generated.

Compound polysaccharides (CP) effectively treated colitis in rats by restoring gut microbiota balance. This suggests CP may serve as a prebiotic agent for managing gut dysbiosis in inflammatory bowel disease.

Keywords:
compound polysaccharidesfunction predictiongut microbiomeinflammatory bowel disease

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Area of Science:

  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • Inflammatory bowel disease (IBD) involves immune dysregulation against gut microbiota in genetically susceptible individuals.
  • Current treatments often have limitations, necessitating novel therapeutic approaches.

Purpose of the Study:

  • To investigate the therapeutic effects of compound polysaccharides (CP) on TNBS-induced colitis in rats.
  • To elucidate the underlying mechanisms involving gut microbiota modulation.

Main Methods:

  • Male Sprague-Dawley rats were induced with colitis using 2,4,6-trinitrobenzenesulfonic acid (TNBS).
  • Rats were treated with CP, and disease activity, serum myeloperoxidase, and gut microbiota composition/function were analyzed.

Main Results:

  • CP significantly reduced inflammation and ameliorated TNBS-induced colitis.
  • CP reversed gut dysbiosis, increasing beneficial short-chain fatty acid (SCFA)-producing bacteria and lactic acid bacteria, while decreasing harmful bacteria.
  • CP restored normal gut microbiota function, improving metabolism and reducing oxidative stress.

Conclusions:

  • Compound polysaccharides demonstrate therapeutic potential for experimental colitis by modulating gut microbiota.
  • CP may function as a prebiotic agent to treat gut dysbiosis associated with colitis.