Related Experiment Video
Updated: Jan 31, 2026
06:48
Breakfast Habits among Schoolchildren in the City of Uruguaiana, Brazil
Published on: July 29, 2020
5.2K
Pharmacogenomics research and clinical implementation in Brazil
Fernanda Rodrigues-Soares1, Guilherme Suarez-Kurtz2
1Faculty Uninassau, Manaus, Brazil.
Basic & Clinical Pharmacology & Toxicology
|December 28, 2018
Summary
Pharmacogenetic (PGx) studies in Brazil focus on CPIC-guided drugs like warfarin. Limited adoption is due to global barriers and Brazil-specific genetic variations and population admixture challenges.
Area of Science:
- Pharmacogenomics
- Genetics
- Clinical Pharmacology
Background:
- Pharmacogenetic (PGx) research in Brazil is crucial for optimizing drug therapy.
- International PGx guidelines often require adaptation for diverse populations.
Purpose of the Study:
- To review pharmacogenetic/genomic (PGx) studies in the Brazilian population.
- To assess the implementation of PGx in Brazil based on Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines.
Main Methods:
- Searched PubMed and Lattes database for Brazilian PGx studies.
- Focused on drugs and genes within CPIC guidelines.
- Examined studies on warfarin, tacrolimus, atazanavir, 5-fluorouracil, PEG-IFN-α, and abacavir.
Main Results:
- Warfarin dosing was extensively studied, identifying VKORC1 and CYP2C9 associations.
- CYP3A5 variants (CYP3A5*6, CYP3A5*7) linked to tacrolimus dosing in renal transplant patients.
- Studies confirmed PGx associations for HIV and cancer therapies, including UGT1A1*28, DPYD, IFNL3, and HLA-B*57:01.
Conclusions:
- Limited adoption of PGx-guided therapy in Brazil stems from global implementation barriers.
- Brazil-specific factors include the rarity of certain genetic variants and challenges in applying guidelines to admixed populations.
Related Concept Videos
01:15Nursing Implementation
6.2K
Implementation is the execution of the nursing care plan developed during the planning phase.
The five steps to implementing effective nursing care include reassessing the patient, reviewing and revising the existing nursing care plan, organizing the resources and care delivery, anticipating and preventing complications, and implementing nursing interventions.
The five steps to implementing effective nursing care include reassessing the patient, reviewing and revising the existing nursing care plan, organizing the resources and care delivery, anticipating and preventing complications, and implementing nursing interventions.
6.2K
01:27Nursing Clinical Information System
1.3K
Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
1.3K
01:16Clinical Trials
10.4K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
10.4K
01:25Role of Communication in the Nursing Process II: Planning and Implementation
2.7K
Several factors are considered while creating a patient's care plan. Motivation is a factor in improving communication, and patients often require encouragement to try different approaches involving significant change. It is essential to involve the patient and family in decisions about the plan of care to determine whether the suggested methods are acceptable. Consider meeting critical comfort and safety needs before introducing new communication methods and techniques. Allow adequate time...
2.7K
01:11Clinical Trials: Overview
4.9K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.9K
01:24Nursing Process for Patient and Caregiver Teaching II: Planning and Implementation
2.1K
Planning for learning involves the development of a teaching plan. Teaching plans are similar to nursing care plans—both follow the steps of the nursing process. Planning in the teaching process involves setting goals and outcomes. Here, goals identify what a patient needs to achieve to understand a healthcare topic better, whereas the outcomes are the action to be performed by the patient to achieve the goal within a timeframe. For example, if the goal is to educate the patient about...
2.1K