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Effect of pregnancy loss on MS disease activity
T B Kaplan1, R Bove2, K Galetta1
1Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Boston, MA, United States.
Objective:
To evaluate the effect of pregnancy loss (PL) on MS disease activity.
Methods:
Eleven women with first-trimester PLs were identified through a reproductive questionnaire. MS activity (MRI lesions and/or clinical relapses) was compared for the 12 months before conception and after PL.
Results:
There was MS activity in 7/11 participants after, compared with 3/11 before PL (McNemar's test, p = .29), including MRI activity in 7/11 after, compared with 2/11 before PL (McNemar's test, p = .13).
Conclusion:
Larger studies are needed to confirm this observed trend of increased MS activity following PL.
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