Related Experiment Video

Updated: Jan 31, 2026

Isolation and Transplantation of Hematopoietic Stem Cells HSCs
20:38

Isolation and Transplantation of Hematopoietic Stem Cells HSCs

Published on: February 25, 2007

24.2K

Hematopoietic Stem Cell Transplantation in Primary Immunodeficiencies Beyond Severe Combined Immunodeficiency

Alexandra F Freeman1

  • 1Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.

Journal of the Pediatric Infectious Diseases Society
|December 28, 2018
PubMed

Insights

Hematopoietic stem cell transplantation (HSCT) is now used for more than severe combined immunodeficiency (SCID) in infants. Advances allow HSCT for other primary immunodeficiencies (PIDs) in older children and adults.

Area of Science:

  • Immunology
  • Pediatric Hematology
  • Stem Cell Transplantation

Background:

  • Hematopoietic stem cell transplantation (HSCT) is the established treatment for infants with severe combined immunodeficiency (SCID).
  • Improvements in HSCT conditioning and supportive care have expanded its application.
  • Expanding donor options, including haploidentical transplants, enhance HSCT accessibility for primary immunodeficiencies (PIDs).

Purpose of the Study:

  • To discuss primary immunodeficiencies (PIDs) for which HSCT is increasingly performed beyond early childhood.
  • To highlight the evolving landscape of HSCT for non-SCID PIDs.

Main Methods:

  • Review of current practices and trends in HSCT for PIDs.
  • Discussion based on a presentation at the 2018 PIDS-St. Jude conference.

Main Results:

  • HSCT is increasingly utilized for a broader range of PIDs, not limited to early childhood SCID.
  • Haploidentical donor transplants show increasing success, broadening donor availability.

Conclusions:

  • HSCT is becoming a more versatile treatment for various PIDs.
  • The indications for HSCT are expanding beyond SCID and early childhood, supported by improved techniques and donor options.

More Related Videos

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness08:53

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Published on: August 31, 2016

15.9K
Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells22:06

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Published on: February 25, 2007

14.0K

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
2.4K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.9K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.1K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.0K
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.9K
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.4K