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Updated: Jan 31, 2026

Derivation of Leptomeninges Explant Cultures from Postmortem Human Brain Donors
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Clinical Vignettes: Donor-Derived Infections.

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Transplant recipients can contract infections from donor organs, even with screening. Infectious disease specialists are crucial for assessing risks and managing infections in solid organ transplantation (SOT).

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Area of Science:

  • Infectious Diseases
  • Transplantation Medicine
  • Public Health

Background:

  • Solid organ transplantation (SOT) carries a risk of pathogen transmission from donor to recipient.
  • Pretransplant screening and prophylaxis strategies exist for common infections like Hepatitis B, CMV, and EBV.

Observation:

  • Despite diagnostic advances, unanticipated pathogen transmission occurs, especially with asymptomatic or subtly infected donors.
  • Donor cause of death and clinical history are vital for assessing infection risk in recipients.
  • Infectious diseases (ID) providers play a key role in risk assessment and guiding transplant teams.

Findings:

  • Close collaboration between ID providers, transplant teams, and organ procurement organizations (OPOs) is essential for managing suspected donor-derived infections.
  • National committees and federal agencies provide oversight for policy development and prevention of donor-transmitted diseases.

Implications:

  • Accurate risk-benefit analysis of organ acceptance is improved by thorough donor evaluation.
  • Effective communication and information sharing are critical for managing infections across multiple recipients from a single donor.
  • Continued vigilance and collaboration are necessary to minimize the risk of infection transmission in organ transplantation.