Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peroxisomes and Mitochondria01:30

Peroxisomes and Mitochondria

95.4K
Peroxisomes and mitochondria are two important oxygen-utilizing organelles in eukaryotic cells. Mitochondria carry out cellular respiration—the process that converts energy from food into ATP. Peroxisomes carry out a variety of functions, primarily breaking down different substances, such as fatty acids.
The peroxisome is a single membrane-bound cellular organelle that can perform several different functions, including lipid metabolism and chemical detoxification. The enzymes within...
95.4K
Composition of Polyprotic Acid Solutions as a Function of pH01:19

Composition of Polyprotic Acid Solutions as a Function of pH

866
Polyprotic acids of the type H2M constitute two ionizable protons. As a result, on titration with a base, they exhibit two equivalence points in the titration curve. During titration, the species H2M, HM−, and M2− will be present in the solution at different points. The fractions of H2M, HM−, and M2− present at the various instances of the titration are denoted by α0, α1, and α2, respectively.
A graph with the alpha values is plotted against the volume of...
866
Protein-protein Interfaces02:04

Protein-protein Interfaces

14.7K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
14.7K
Mitochondria01:37

Mitochondria

20.4K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
20.4K
Molecular Models02:00

Molecular Models

43.7K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.7K
Classifying Matter by Composition03:35

Classifying Matter by Composition

90.4K
Matter: Pure Substances and Mixtures
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures. 
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated. 
A mixture is composed of two or...
90.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SAR-driven optimization of 2-amino-oxazole-based dual CSF-1R/c-Kit inhibitors for neuroinflammation.

European journal of medicinal chemistry·2026
Same authorSame journal

Adherent-to-suspension transition modulates circulating tumor cell dynamics and metastatic potential in melanoma.

Molecules and cells·2026
Same author

Reliable Object Pose Alignment in Mixed-Reality Environments Using Background-Referenced 3D Reconstruction.

Sensors (Basel, Switzerland)·2026
Same author

Occupational Exposure Risk and Safety of Novel Intraperitoneal Oxaliplatin Delivery via Heated CO<sub>2</sub> and Dual-flow Nozzle System.

Safety and health at work·2026
Same author

Broadband Circularly Polarized Light Detection via Spin-Selective Charge Transport in Quantum Dot Photodiodes.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Proteomics of extracellular vesicles derived from Lactobacillus: Implications in gut immune homeostasis and therapeutic potential.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026

Related Experiment Video

Updated: Jan 31, 2026

Multiscale Sampling of a Heterogeneous Water/Metal Catalyst Interface using Density Functional Theory and Force-Field Molecular Dynamics
10:52

Multiscale Sampling of a Heterogeneous Water/Metal Catalyst Interface using Density Functional Theory and Force-Field Molecular Dynamics

Published on: April 12, 2019

13.4K

The Interface Between ER and Mitochondria: Molecular Compositions and Functions.

Soyeon Lee1,2, Kyung-Tai Min1,2

  • 1Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Korea.

Molecules and Cells
|December 29, 2018
PubMed
Summary

Mitochondria and endoplasmic reticulum communicate via the mitochondrial-associated ER membrane (MAM), regulating cell functions. Disruptions in this vital ER-mitochondrial crosstalk are implicated in neurodegenerative diseases.

Keywords:
ER-mitochondria tetheringmitochondrial-associated ER membrane (MAM)neurodegenerative disease

More Related Videos

Characterizing the Composition of Molecular Motors on Moving Axonal Cargo Using "Cargo Mapping" Analysis
11:09

Characterizing the Composition of Molecular Motors on Moving Axonal Cargo Using "Cargo Mapping" Analysis

Published on: October 30, 2014

9.9K
Isolation and Functional Analysis of Mitochondria from Cultured Cells and Mouse Tissue
09:27

Isolation and Functional Analysis of Mitochondria from Cultured Cells and Mouse Tissue

Published on: March 23, 2015

40.6K

Related Experiment Videos

Last Updated: Jan 31, 2026

Multiscale Sampling of a Heterogeneous Water/Metal Catalyst Interface using Density Functional Theory and Force-Field Molecular Dynamics
10:52

Multiscale Sampling of a Heterogeneous Water/Metal Catalyst Interface using Density Functional Theory and Force-Field Molecular Dynamics

Published on: April 12, 2019

13.4K
Characterizing the Composition of Molecular Motors on Moving Axonal Cargo Using "Cargo Mapping" Analysis
11:09

Characterizing the Composition of Molecular Motors on Moving Axonal Cargo Using "Cargo Mapping" Analysis

Published on: October 30, 2014

9.9K
Isolation and Functional Analysis of Mitochondria from Cultured Cells and Mouse Tissue
09:27

Isolation and Functional Analysis of Mitochondria from Cultured Cells and Mouse Tissue

Published on: March 23, 2015

40.6K

Area of Science:

  • Cell Biology
  • Neuroscience
  • Biochemistry

Background:

  • Mitochondria and endoplasmic reticulum (ER) are crucial eukaryotic organelles.
  • Mitochondria are vital for ATP production, calcium (Ca2+) homeostasis, and apoptosis.
  • ER regulates protein folding, lipid metabolism, and Ca2+ homeostasis.

Purpose of the Study:

  • To review the molecular components of the mitochondrial-associated ER membrane (MAM).
  • To elucidate how MAM regulates cellular functions.
  • To discuss the role of impaired ER-mitochondrial communication in neurodegenerative diseases.

Main Methods:

  • Literature review of molecular junctions forming MAM.
  • Analysis of MAM's regulatory roles in cellular processes.
  • Examination of scientific literature on neurodegenerative diseases linked to MAM dysfunction.

Main Results:

  • MAM acts as a critical communication hub between mitochondria and ER.
  • This crosstalk is essential for energy production, lipid processing, Ca2+ buffering, and apoptosis.
  • Defects in MAM signaling significantly impact cell survival and death.

Conclusions:

  • Understanding MAM components and functions is key to cellular regulation.
  • Impaired ER-mitochondrial communication via MAM is a significant factor in neurodegenerative disease pathogenesis.
  • Further research into MAM could reveal therapeutic targets for these conditions.