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High correlation between human rhinovirus type C and children with asthma exacerbations in Taiwan

Yu-Tsun Su1, Yen-Ting Lin2, Ching-Chi Yang3

  • 1Division of Pediatric Allergy, Immunology, and Pulmonology, Department of Pediatrics, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan; School of Medicine for International Students, I-Shou University, Kaohsiung, Taiwan; School of Chinese Medicine for Post Baccalaureate, I-Shou University, Kaohsiung, Taiwan.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|December 29, 2018
PubMed

Insights

Human rhinovirus (HRV) and particularly HRV type C (HRV-C) are linked to asthma exacerbations in Taiwanese children. HRV-C was found to be the most common HRV type causing these exacerbations.

Area of Science:

  • Pediatric Respiratory Medicine
  • Virology
  • Asthma Research

Background:

  • Human rhinovirus type C (HRV-C) is associated with asthma exacerbations (AE) in children globally.
  • The specific association between HRV, especially HRV-C, and AE in Taiwanese children remains under-investigated.

Purpose of the Study:

  • To determine the prevalence of respiratory viruses in children with acute lower respiratory tract infection (ALRTI) in Taiwan.
  • To investigate the association between different HRV types and AE in children.

Main Methods:

  • A prospective study from 2011-2013 enrolled children with ALRTI, divided into an asthma exacerbation (AE) group (n=28) and a Non-asthma group (n=66).
  • Nasopharyngeal swabs were analyzed for viruses using culture, reverse transcription-polymerase chain reaction (RT-PCR), and molecular sequencing.

Main Results:

  • Respiratory viruses were detected in 78.6% of the AE group and 65.2% of the Non-asthma group.
  • HRV and HRV-C prevalence were significantly higher in the AE group (HRV: 67.9% vs 33.3%; HRV-C: 50% vs 15.2%).
  • In the AE group, HRV-C constituted 68.4% of HRV infections, significantly more than HRV-A (26.3%) or HRV-B (5.3%).

Conclusions:

  • Human rhinovirus (HRV) is the primary viral pathogen causing pediatric asthma exacerbations in Taiwan.
  • HRV type C is a more frequent cause of pediatric AE in Taiwan compared to HRV-A and HRV-B.
Abstract

Keywords:
AsthmaAsthma exacerbationChildrenRhinovirusRhinovirus C

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