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Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood
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Anticoagulant Therapy for Disseminated Intravascular Coagulation After Gastrointestinal Surgery

Daisuke Hashimoto1,2, Takaomi Okawa2, Riichiroh Maruyama3

  • 1Department of Gastroenterological Surgery, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan daisukeh007@gmail.com.

Anticancer Research
|December 29, 2018
PubMed

Insights

Anticoagulant therapy for disseminated intravascular coagulation (DIC) after gastrointestinal surgery shows promise. Agents like gabexate mesylate, antithrombin, and recombinant thrombomodulin appear effective and safe, improving outcomes without significant bleeding risks.

Area of Science:

  • Medical research
  • Pharmacology
  • Gastroenterology

Background:

  • Disseminated intravascular coagulation (DIC) following gastrointestinal surgery presents unique challenges.
  • Distinguishing surgery-related DIC from other forms is crucial for effective treatment.
  • Anticoagulant therapy's efficacy and safety in this context require careful evaluation due to bleeding risks.

Purpose of the Study:

  • To systematically review the efficacy and safety of anticoagulant agents for treating DIC specifically after gastrointestinal surgery.
  • To clarify the benefits and risks associated with different anticoagulant options in this patient population.

Main Methods:

  • Systematic literature review of studies on anticoagulant therapy for post-gastrointestinal surgery DIC.
  • Analysis of data on DIC scores, bleeding events, and mortality rates.

Main Results:

  • Gabexate mesylate demonstrated improvement in DIC scores without increased bleeding.
  • Antithrombin was linked to reduced mortality in patients with DIC post-gastrointestinal surgery.
  • Recombinant thrombomodulin showed improved DIC scores and survival rates, with no increase in bleeding events.

Conclusions:

  • Anticoagulant therapy is a potentially effective and safe treatment strategy for DIC occurring after gastrointestinal surgery.
  • Specific agents like recombinant thrombomodulin show particular promise in improving patient outcomes.

Keywords:
Disseminated intravascular coagulationanticoagulant therapybleedingcomplicationoperationreview

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