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MicroRNA Expression in the Progression and Aggressiveness of Papillary Thyroid Carcinoma

Agnieszka Zembska1, Aleksandra Jawiarczyk-Przybyłowska2, Beata Wojtczak3

  • 1Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wroclaw, Poland aga.zembska@gmail.com.

Anticancer Research
|December 29, 2018
PubMed

Insights

MicroRNAs regulate gene expression and are linked to various diseases. This review explores microRNA

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are key regulators of gene expression, gaining significant research attention over the past two decades.
  • While miRNA defects are implicated in numerous diseases, their specific role in thyroid disorders remains underexplored.
  • Papillary thyroid carcinoma (PTC) is a common endocrine malignancy with potential links to miRNA dysregulation.

Purpose of the Study:

  • To review the current understanding of microRNA origin, biogenesis, and function.
  • To examine the differential expression of miRNAs in papillary thyroid carcinoma.
  • To discuss the impact of Single Nucleotide Polymorphisms (SNPs) in miRNAs concerning PTC.

Main Methods:

  • Literature review of scientific publications on microRNAs and thyroid cancer.
  • Analysis of studies reporting miRNA expression profiles in papillary thyroid carcinoma.
  • Review of research on the genetic variations (SNPs) within miRNA genes and their association with PTC.

Main Results:

  • MicroRNAs play a crucial role in gene expression regulation.
  • Dysregulated miRNAs are associated with thyroid dysfunction and the development of papillary thyroid carcinoma.
  • Single Nucleotide Polymorphisms in miRNAs can influence the risk or progression of papillary thyroid carcinoma.

Conclusions:

  • MicroRNAs are significant factors in thyroid disease pathogenesis, particularly in papillary thyroid carcinoma.
  • Further research into miRNA dysregulation and genetic variations is warranted for understanding and potentially treating thyroid cancer.
  • Targeting miRNAs may offer novel therapeutic strategies for papillary thyroid carcinoma.
Keywords:
MicroRNASNPcirculating microRNAgene expressionpapillary thyroid cancerreview

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