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A Single Nucleotide Polymorphism in SLC7A5 Was Associated With Clinical Response in Multiple Myeloma Patients

Ming J Poi1,2,3, Junan Li1,4, Jasmine A Johnson5

  • 1Division of Pharmacy Practice and Science, College of Pharmacy, The Ohio State University, Columbus, OH, U.S.A. poi.2@osu.edu li.225@osu.edu.

Anticancer Research
|December 29, 2018
PubMed
Abstract

Insights

A specific gene variant (rs4240803) in SLC7A5 influences melphalan treatment response in multiple myeloma (MM) patients. This finding may help personalize melphalan therapy for better outcomes.

Area of Science:

  • Pharmacogenomics
  • Oncology
  • Molecular Biology

Background:

  • Solute carrier family 7 member 5 (SLC7A5) is crucial for melphalan uptake in multiple myeloma (MM) cells.
  • Inter-patient variability in melphalan efficacy and toxicity is not fully understood.
  • The role of genetic variations in SLC7A5 in melphalan response requires further investigation.

Purpose of the Study:

  • To examine the impact of the single nucleotide polymorphism (SNP) rs4240803 in SLC7A5.
  • To assess the effect of rs4240803 on SLC7A5 gene expression.
  • To evaluate the association of rs4240803 with ex vivo melphalan sensitivity and clinical outcomes in MM patients undergoing autologous stem cell transplantation.

Main Methods:

  • Collected peripheral blood mononuclear cells (PBMCs) from 108 MM patients before melphalan therapy.
  • Gathered clinical data from patients post-melphalan therapy.
  • Analyzed the association between the SLC7A5 rs4240803 polymorphism, gene expression, ex vivo sensitivity, and clinical response.

Main Results:

  • The rs4240803 polymorphism was linked to increased SLC7A5 mRNA expression.
  • Patients with rs4240803 showed higher ex vivo sensitivity to melphalan in PBMCs.
  • A positive 90-day response was observed in patients with the rs4240803 variant (p=0.049).

Conclusions:

  • The rs4240803 polymorphism in SLC7A5 influences gene expression.
  • This genetic variation contributes to the clinical response of multiple myeloma patients to melphalan therapy.
Keywords:
Multiple myelomaSLC7A5clinical responsemelphalan

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