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Infarct Volume Predicts Hospitalization Costs in Anterior Circulation Large-Vessel Occlusion Stroke.

C D Streib1,2, S Rangaraju2,3, D T Campbell2,4

  • 1From the Department of Neurology (C.D.S., A.J.Z.), University of Minnesota, Minneapolis, Minnesota.

AJNR. American Journal of Neuroradiology
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Final infarct volume is the primary driver of hospitalization costs for anterior circulation large-vessel occlusion stroke. Reducing infarct size through acute stroke therapies may improve outcomes and reduce healthcare expenses.

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Area of Science:

  • Neurology
  • Health Economics
  • Stroke Research

Background:

  • Anterior circulation large-vessel occlusion stroke is a severe subtype with significant economic impact.
  • Understanding cost predictors is crucial for managing healthcare resources.

Purpose of the Study:

  • To identify predictors of acute care hospitalization costs in patients with anterior circulation large-vessel occlusion stroke.
  • To analyze cost variations based on stroke characteristics and treatment modalities.

Main Methods:

  • Utilized comprehensive cost-tracking software for 341 patients (July 2012-October 2014).
  • Analyzed patient demographics, stroke characteristics, and final infarct volume.
  • Employed multivariable linear regression and subgroup analyses based on treatment (endovascular, IV tPA-only, no reperfusion).

Main Results:

  • Final infarct volume, parenchymal hematoma, NIHSS score, carotid stenosis, age, and sleep apnea predicted costs.
  • Final infarct volume alone explained 20.87% of cost variance.
  • Infarct volume was the strongest predictor across all analyses.

Conclusions:

  • Final infarct volume is the leading predictor of increased hospitalization costs in this stroke subtype.
  • Acute stroke therapies aimed at reducing infarct volume may offer both clinical and economic benefits.