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Clinical safety profile of ticagrelor compared to clopidogrel in 1208 patients: Real world evidence

Viveka Kumar1, Vivek Kumar1, Kajal Kumari2

  • 1Department of Cardiology, Max Super Speciality Hospital, Saket, New Delhi, India.

The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology
|December 29, 2018
PubMed

Insights

Ticagrelor and clopidogrel show similar safety profiles for patients undergoing PCI, with no significant differences in major bleeding events. However, ticagrelor was associated with a higher rate of minor bleeding in real-world Indian patient data.

Area of Science:

  • Cardiology
  • Pharmacology
  • Clinical Research

Background:

  • Dual antiplatelet therapy is standard post-PCI.
  • The PLATO trial favored ticagrelor over clopidogrel for ACS patients.
  • Limited real-world data exists for Indian populations.

Purpose of the Study:

  • To compare the safety of ticagrelor versus clopidogrel.
  • To evaluate real-world outcomes in Indian patients undergoing PCI.
  • To assess bleeding rates and other safety endpoints.

Main Methods:

  • Retrospective observational study of 1208 patients undergoing PCI.
  • Patients treated with either ticagrelor or clopidogrel.
  • Analysis of in-hospital outcomes and bleeding events.

Main Results:

  • No significant difference in major or life-threatening bleeding between ticagrelor and clopidogrel groups.
  • Ticagrelor group showed a statistically significant increase in minor bleeding events (21.4% vs. 13.6%).
  • Overall safety profile was comparable, aligning with PLATO trial findings.

Conclusions:

  • Ticagrelor demonstrates a similar safety profile to clopidogrel in real-world PCI patients in India.
  • Increased minor bleeding rates with ticagrelor warrant consideration.
  • Findings support existing clinical trial data in a different population.
Abstract

Keywords:
AntiplateletP2Y12 inhibitorsPercutaneous coronary intervention

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