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Effect of Fructus schisandrae syrup on bronchial asthma mice model
Mengfan Peng1, Mingsan Miao1, Tan Wang1
1College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Purpose:
To investigate the effect of Fructus schisandrae syrup on bronchial asthma mice model.
Methods:
Sixty Kunming mice were randomly divided into normal control group, bronchial asthma model group, low-, middle-, and high-dose Fructus schisandrae syrup groups. Bronchial asthma was induced by injection of ovalbumin combined smoking. Two hours after the last administration, the change of lung function were observed, the contents of NO, IL-6 in serum were detected, the morphological changes of lung and bronchial were also observed, so as to explore the effect of Fructus schisandrae syrup on bronchial asthma mice.
Results:
Compared with model group, the Schisandrae Fructus syrup groups can significantly increase the tidal volume of mice and decrease the respiratory frequency and the degree of bronchial stenosis (P < 0.01); The Schisandrae Fructus syrup groups can decrease the levels of NO and IL-6 in serum and improve the pathological changes of lung and bronchus in different degrees.
Conclusion:
Fructus schisandrae syrup can significantly improve the biochemical indexes and pathological status of mice with bronchial asthma.
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