Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cardiomyopathy VII: Pre and Post Operative Nursing Management

Cardiomyopathy VII: Pre and Post Operative Nursing Management

Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...

False Memories

False Memories

False memories represent a cognitive distortion in which individuals recall events that did not happen, or remember them in an altered form. This phenomenon highlights the brain's constructive nature in processing and recalling memories, emphasizing that memory is not a perfect representation of past events but rather a dynamic reconstruction influenced by various factors.
One primary source of false memories is misattribution, where individuals incorrectly associate external information...

Ethical Issues

Ethical Issues

Nurses are essential in patient care, upholding the ethical principles of their profession and effectively navigating ethical dilemmas. Neglecting ethical issues can lead to inadequate patient care, compromised therapeutic relationships, and moral distress among healthcare workers.
Ethical Concerns in Healthcare:

Partial Fractions

Partial Fractions

A partial fraction is a component of a rational expression represented as the sum of simpler fractions. When a rational function is expressed as a ratio of two polynomials, it can often be decomposed into a sum of fractions whose denominators are simpler polynomials, typically linear or irreducible quadratic factors. This process is called partial fraction decomposition, and it is used to simplify complex expressions for integration, solving equations, or analysis.Partial fraction decomposition...

pre-mRNA Processing

pre-mRNA Processing

In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a “cap” to the 5’ end of the growing transcript. In this process, a 5’ phosphate is replaced by modified guanosine that has a methyl group attached to it (7-Methyl...

Issues And Trends In Healthcare Delivery System

Issues And Trends In Healthcare Delivery System

The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Interference and misleading blood test results].

Ugeskrift for laeger·2026

Same author

Stability of whole blood samples at different temperatures: a systematic review.

Diagnosis (Berlin, Germany)·2026

Same author

Evaluation of AI-assisted chart review for acute myocardial infarction and cardiogenic shock.

Danish medical journal·2026

Same author

Performance evaluation of the new Sysmex XR9000 hematology system in a clinical setting in comparison with Sysmex XN9100.

Scandinavian journal of clinical and laboratory investigation·2026

Same author

Recommendation on quality assurance of pneumatic transportation systems an opinion paper from the Nordic preanalytical scientific working group.

Scandinavian journal of clinical and laboratory investigation·2026

Same author

[Present and future use of point-of-care testing].

Ugeskrift for laeger·2026

Search research articles

Related Experiment Video

Updated: Jan 31, 2026

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

Falsely prolonged activated partial thromboplastin time - a pre- and post-analytical issue.

Charlotte Gils¹, Pernille Just Vinholt¹, Mads Nybo¹

¹Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.

Biochemia Medica

|December 29, 2018

Summary

Two common pre-analytical issues in activated partial thromboplastin time (aPTT) testing were missed due to error codes. This case emphasizes careful interpretation of coagulation test results, especially with interfering factors.

Keywords:

activated partial thromboplastin time haemolysis lipemia post-analytical errors pre-analytical errors

More Related Videos

Simultaneous Pre- and Post-synaptic Electrophysiological Recording from Xenopus Nerve-muscle Co-cultures

Simultaneous Pre- and Post-synaptic Electrophysiological Recording from Xenopus Nerve-muscle Co-cultures

Published on: March 11, 2013

Partial Hepatectomy in Adult Zebrafish

Partial Hepatectomy in Adult Zebrafish

Published on: April 4, 2021

Related Experiment Videos

Last Updated: Jan 31, 2026

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

Simultaneous Pre- and Post-synaptic Electrophysiological Recording from Xenopus Nerve-muscle Co-cultures

Simultaneous Pre- and Post-synaptic Electrophysiological Recording from Xenopus Nerve-muscle Co-cultures

Published on: March 11, 2013

Partial Hepatectomy in Adult Zebrafish

Partial Hepatectomy in Adult Zebrafish

Published on: April 4, 2021

Area of Science:

Clinical Chemistry
Hematology
Laboratory Medicine

Background:

Routine coagulation testing, specifically activated partial thromboplastin time (aPTT), is crucial for diagnosing bleeding disorders.
Pre-analytical variables can significantly impact the accuracy of coagulation test results.

Observation:

A pediatric case presented with gastrointestinal bleeding and an initially reported prolonged aPTT (>300 seconds).
The prolonged aPTT result was flagged as 'no coagulation' and replaced with asterisks, initially suggesting hemophilia.
Subsequent testing using a different analytical principle revealed a normal aPTT.

Findings:

The initial prolonged aPTT was an artifact caused by concurrent sample interferences: hemolysis and lipemia.
These pre-analytical interferences were misinterpreted as a genuine coagulation defect due to overriding flag codes.
Normal levels of coagulation factors VIII and IX ruled out hemophilia.

Implications:

Highlights the critical need for awareness of multiple, potentially overriding, flag codes in laboratory diagnostics.
Emphasizes the importance of the post-analytical phase, requiring enhanced education for laboratory professionals.
Suggests a need for improved communication and collaboration between manufacturers and clinical laboratories to address such pre-analytical challenges.