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Updated: Jan 31, 2026

Demonstration of the Rat Ischemic Skin Wound Model
Published on: April 1, 2015
Skin Perfusion Pressure and Wound Closure Time in Lower Extremity Wounds
Kazu Suzuki1, Zoe Birnbaum1, Ryan Lockhart1
1Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Introduction:
Peripheral Arterial Disease (PAD) affects approximately 8 million patients in the United States. We investigate the relationship of Skin Perfusion Pressure (SPP) and wound closure time in lower extremity wounds.
Methods:
We conducted a retrospective study of 1125 lower extremity wounds in 998 patients between June 2006 and October 2014 in our wound clinic. We analyzed the relationship between SPPand wound closure time. SPP was measured using a Laser Doppler instrument.
Results:
Patients with SPP values over 30 mmHg had shorter wound closure times, while patients with SPP values below 30 mmHg had a significantly longer wound closure time. Diabetic patients took longer to achieve wound closure compared to non-diabetics. No significant relationship was observed between SPP and wound closure time in relation to age or gender.
Conclusion:
SPP is a useful tool in estimating time to wound closure and assessing the necessity of vascular interventions in lower extremity wounds.
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