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Updated: Jan 31, 2026

Mouse Model of Pressure Ulcers After Spinal Cord Injury
Published on: March 9, 2019
Pressure Ulcer in Trauma Patients: A Higher Spinal Cord Injury Level Leads to Higher Risk
Areg Grigorian1, Megumi Sugimoto1, Victor Joe1
1University of California, Irvine, Department of Surgery, Division of Trauma, Burns and Surgical Critical Care, Orange, CA, USA.
Higher spinal cord injury (SCI) levels significantly increase the risk of developing pressure ulcers (PUs) in trauma patients. This contrasts with prior research, highlighting a critical factor in acute trauma care.
Area of Science:
- Trauma Surgery
- Neurosurgery
- Wound Care
Background:
- Previous systematic reviews indicated no association between spinal cord injury (SCI) level and pressure ulcer (PU) risk.
- This study hypothesized that upper-SCI (cervical/thoracic) presents a higher PU risk than lower-SCI (lumbar/sacral) in acute trauma.
Purpose of the Study:
- To investigate the association between SCI level and PU development in acute trauma patients.
- To identify risk factors for PUs in trauma patients with SCI.
Main Methods:
- Retrospective analysis of the National Trauma Data Bank (NTDB) from 2007-2015.
- Multivariable logistic regression analysis was employed to determine PU risk factors.
Main Results:
- Of 62,929 patients with SCI (0.9%), 5.1% developed PUs.
- Patients with upper-SCI had a significantly higher incidence of PUs (5.8%) compared to lower-SCI (2.2%).
- SCI was the strongest predictor for PU (OR=13.77), with upper-SCI showing a 2.81-fold greater risk than lower-SCI.
Conclusions:
- A higher SCI level is associated with a three-fold greater risk for PU development compared to lower SCI levels.
- Findings contradict previous reports, emphasizing the importance of SCI level in PU risk stratification for trauma patients.
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