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Gastrointestinal defects in gallstone and cholecystectomized patients
Agostino Di Ciaula1, Emilio Molina-Molina2, Leonilde Bonfrate2,3
1Division of Internal Medicine, Hospital of Bisceglie, ASL BAT, Bisceglie, Italy.
European Journal of Clinical Investigation
|December 29, 2018
Summary
Gallstone patients experience dyspeptic symptoms due to gastrointestinal motility defects. These issues persist and worsen after gallbladder removal (cholecystectomy), affecting stomach and small intestine function.
Area of Science:
- Gastroenterology
- Digestive Physiology
Background:
- Dyspeptic symptoms are common in gallstone patients, even without typical pain.
- These symptoms often persist post-cholecystectomy.
- Limited research exists on dyspepsia and gastrointestinal motility in gallstone patients.
Purpose of the Study:
- To investigate dyspepsia and gastrointestinal motor function in gallstone patients.
- To compare these functions in patients with and without gallbladders.
- To assess changes after cholecystectomy.
Main Methods:
- Compared 46 gallstone patients, 24 cholecystectomized patients, and 65 controls.
- Assessed dyspepsia via questionnaire.
- Measured gallbladder and gastric emptying (ultrasound) and orocecal transit time (hydrogen breath test).
Main Results:
- Gallstone patients showed increased dyspepsia, larger gallbladder volumes, and slower gallbladder/gastric emptying and intestinal transit than controls.
- Cholecystectomized patients had further delayed gastric emptying compared to both groups.
Conclusions:
- Gallstone patients, with or without a gallbladder, experience dyspeptic symptoms.
- These symptoms correlate with multiple gastrointestinal motility defects.
- Gastric emptying deteriorates after cholecystectomy.
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