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Related Concept Videos

Polymers02:34

Polymers

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The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
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Heat is a widely used method to control microbial growth by targeting and denaturing cellular proteins, thereby killing or inactivating microbes. This method's effectiveness is quantified using parameters such as the thermal death point (TDP), thermal death time (TDT), and decimal reduction time (D value). TDP represents the lowest temperature at which all microorganisms in a liquid suspension are eliminated within 10 minutes, whereas TDT is the time necessary to achieve sterilization at a...
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The uterine or fallopian tubes function as the conduit through which oocytes travel from the ovaries to the uterus. Each fallopian tube measures approximately 10 to 13 cm long and is anatomically divided into the infundibulum, ampulla, isthmus, and interstitial part (or intramural segment). The infundibulum is characterized by its funnel shape and features extensions called fimbriae which reach towards the peritoneal cavity. These fimbriae play a critical role during ovulation as they extend...
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Endotracheal tube extubation is a critical procedure in weaning patients from mechanical ventilation. It involves physically removing the oral or nasal endotracheal (ET) tube, marking the final step in liberating a patient from ventilatory support.
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A tracheostomy is a surgical procedure that creates an artificial opening into the trachea, typically at the second or third cartilaginous ring level. This opening allows the insertion of a tracheostomy tube, which can replace an endotracheal tube, provide mechanical ventilation, bypass an upper airway obstruction, or remove accumulated tracheobronchial secretions.
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Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
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Temperature-Controlled Microfluidic System Incorporating Polymer Tubes.

Jiu Yang Zhu1, Ngan Nguyen1, Sara Baratchi2

  • 1School of Engineering , RMIT University , Melbourne , Victoria 3001 , Australia.

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|December 29, 2018
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Summary
This summary is machine-generated.

This study presents a versatile microfluidic system for precise temperature control of samples. The novel design allows for dynamic thermal conditions, crucial for studying temperature-sensitive biological and chemical processes.

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Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Cellular Biology

Background:

  • Precise temperature control is essential for studying cellular responses.
  • Existing microfluidic systems often lack dynamic thermal control capabilities.

Purpose of the Study:

  • To develop a user-friendly microfluidic system for precise sample temperature regulation.
  • To enable dynamic and static thermal condition studies for biological samples.

Main Methods:

  • Integration of a multilayered microfluidic chip with commercial polymer tubing.
  • Modulation of water flow rate and inlet temperature for precise thermal control.
  • Creation of temperature gradients by mismatching inlet temperatures.

Main Results:

  • Demonstrated highly controllable temperature profiles under static and dynamic conditions.
  • Successfully created customized temperature gradients across microfluidic channels.
  • Showcased system utility in studying drug-induced calcium signaling in human monocytes under dynamic thermal stress.

Conclusions:

  • The developed microfluidic system offers a versatile and simple solution for temperature control.
  • This technology facilitates research on temperature-sensitive chemical, biochemical, and biological samples.
  • The system's adaptability supports diverse experimental requirements for thermal studies.