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Pharmacotherapeutic strategies for treating pancreatic cancer: advances and challenges

Maria Diab1, Asfar Azmi1, Ramzi Mohammad1

  • 1a Department of Oncology, Karmanos Cancer institute , Wayne State University , Detroit , MI , USA.

Expert Opinion on Pharmacotherapy
|December 29, 2018
PubMed
Abstract

Insights

Pancreatic ductal adenocarcinoma (PDAC) treatment faces challenges due to late diagnosis and drug resistance. This review explores novel chemotherapy and targeted agents for advanced PDAC, aiming to improve patient outcomes.

Area of Science:

  • Oncology
  • Gastroenterology
  • Pharmacology

Background:

  • Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, often due to late detection and resistance to therapies.
  • Improving systemic treatment is critical for enhancing patient outcomes in PDAC.

Purpose of the Study:

  • This review focuses on novel chemotherapy and targeted agents for advanced-stage PDAC.
  • It aims to provide an overview of emerging therapeutic strategies.

Main Methods:

  • Literature review of current and emerging treatments for PDAC.
  • Analysis of novel chemotherapy, targeted agents, and immunotherapies.

Main Results:

  • Current frontline therapies include gemcitabine (GEM) plus nab-paclitaxel or FOLFIRINOX.
  • Targeted therapies are emerging in areas like DNA repair, stroma, metabolism, and stem cells.
  • Immunotherapy has not yet shown significant benefits for PDAC.

Conclusions:

  • Despite advances, specific targeted agents for common PDAC mutations (KRAS, p53, CDK2NA) are lacking.
  • A combination of conventional, immunological, and novel approaches is essential for optimal PDAC patient care.
Keywords:
Chemotherapyimmunotherapypancreatic cancerpathwaystroma

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