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[Initial antibacterial prophylaxis after bone marrow allograft. Pilot study with systemic vancomycin]
1Médecine Infantile B, Centre Hospitalier Universitaire Toulouse-Purpan, France.
Insights
Complete gastrointestinal decontamination and vancomycin prophylaxis effectively prevented Gram-positive septicemia in bone marrow transplant patients. No infectious deaths occurred, demonstrating a safe and effective prophylactic strategy.
Area of Science:
- Hematology
- Infectious Diseases
- Gastroenterology
Abstract:
In 22 consecutive patients treated by allogenic bone marrow transplantation, the authors report their experience in complete gastrointestinal decontamination and prophylactic systemic vancomycin. Neither septicemia from the low digestive tract nor with Gram positive is noticed. A child developed septicemia with Capnocytophaga ochracea, resistant to vancomycin. There is no infectious death in this study and no significative toxicity is reported.