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Echocardiographic and Histological Examination of Cardiac Morphology in the Mouse
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A histopathologic schema to quantify the burden of cardiac amyloidosis: Relationship with survival and

Priya Mehta1, David B Chapel1, Neha Goyal1

  • 1Departments of Medicine, University of Chicago, Chicago, Illinois.

Echocardiography (Mount Kisco, N.Y.)
|December 29, 2018
PubMed

Insights

Cardiac amyloidosis (CA) burden impacts survival. Echocardiography parameters correlate with CA burden, offering potential prognostic insights. Further research is needed to validate these imaging biomarkers.

Area of Science:

  • Cardiology
  • Pathology
  • Medical Imaging

Background:

  • Echocardiographic parameters for cardiac amyloidosis (CA) severity lack validation.
  • A histopathologic schema was developed to quantify CA burden.
  • The relationship between CA burden and clinical outcomes was evaluated.

Purpose of the Study:

  • To validate echocardiographic parameters for assessing cardiac amyloidosis (CA) burden.
  • To correlate histopathologic CA burden with clinical outcomes.
  • To explore echocardiographic parameters as noninvasive indices of CA burden.

Main Methods:

  • Retrospective study of 59 patients with CA (light chain and transthyretin types).
  • Endomyocardial biopsies analyzed using light microscopy with staining to categorize CA burden (mild-to-moderate vs. high).
  • Echocardiographic parameters (EF, IVSt, PWt, LV mass, e'-velocity, GLS) measured and compared between groups.

Main Results:

  • 24 patients had high CA burden, associated with worse mortality, particularly in transthyretin-type CA.
  • Echocardiography-derived IVSt, PWt, and LV mass positively correlated with CA burden.
  • LV EF, e'-velocity, and GLS magnitude inversely correlated with CA burden.

Conclusions:

  • CA burden is clinically significant and offers prognostic information.
  • Echocardiographic parameters of LV anatomy and function correlate with histopathologic CA burden.
  • Further studies are needed to establish echocardiography as a biomarker for treatment response in CA.
Abstract

Keywords:
cardiac amyloidosisechocardiographyendomyocardial biopsylongitudinal strain

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