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Updated: Jan 31, 2026
Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
[Advances in sepsis induced immunosuppression and immunomodulation therapy]
Xuemei He1, Lulong Bo, Chunling Jiang
1Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China (He XM, Jiang CL); Faculty of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai 200433, China (Bo LL). Corresponding author: Jiang Chunling,
Objective:
Immunosuppression plays a vital role in the pathophysiological mechanism of sepsis, and it is the main cause of death in patients with sepsis during the later phase. Sepsis induced immunosuppression is gradually recognized. Its underlying mechanisms involve immune cell apoptosis, autophagy, cell metabolism reprogramming, endotoxin tolerance, central nervous system regulation, and epigenetic regulation. New approaches that target the host immune response and reconstruct the immune balance are the keys to improve the prognosis of patients with sepsis. With the help of immune status monitor, novel immunomodulatory agents, such as thymosin α1, γ- interferon (IFN-γ), interleukin-7 (IL-7), granulocyte-macrophage colony stimulating factor (GM-CSF) and anti-programmed death receptor 1 (PD-1) antibody, are expected to become a new strategy for the treatment of sepsis in future.
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