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Outcomes after toxic alcohol poisoning: a systematic review protocol
Carol Wang1,2, Daniel Samaha2,3, Swapnil Hiremath2,3,4
1Department of Medicine, University of Ottawa, 162 Parkdale Avenue, Ottawa, Ontario, K1Y 1J8, Canada.
Systematic Reviews
|December 30, 2018
Summary
This systematic review examines outcomes of toxic alcohol poisoning, including methanol and ethylene glycol. It aims to improve management guidelines and patient follow-up for better clinical outcomes.
Area of Science:
- Toxicology
- Clinical Medicine
- Systematic Reviews
Background:
- Toxic alcohol ingestions present diagnostic and management challenges.
- Existing guidelines primarily cover methanol and ethylene glycol, with limited consensus on other toxic alcohols.
- Variations in treatment, including antidotes and dialysis, persist due to knowledge gaps.
Purpose of the Study:
- To systematically review short- and long-term patient outcomes following toxic alcohol poisoning.
- To synthesize evidence on methanol, ethylene glycol, isopropanol, propylene glycol, and diethylene glycol poisonings.
- To inform the development of uniform management guidelines and improve patient care.
Main Methods:
- Comprehensive literature search across PubMed, MEDLINE, and EMBASE without date or language restrictions.
- Inclusion of observational studies and clinical trials, with data extraction and quality assessment by two independent investigators.
- Pooled analysis of mortality and secondary outcomes, with subgroup analyses and potential meta-analysis.
Main Results:
- This section is to be populated upon study completion.
Conclusions:
- This systematic review will enhance understanding of patient morbidity and mortality after toxic alcohol poisoning.
- Findings will aid in developing standardized management guidelines and identifying research gaps.
- Evidence generated will support the implementation of effective post-treatment follow-up strategies.
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