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Association of feline morbillivirus infection with defined pathological changes in cat kidney tissues

Kripitch Sutummaporn1, Kazuhiko Suzuki2, Noboru Machida3

  • 1Laboratory of Veterinary Microbiology, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, 183-8509, Japan; The United Graduate School of Veterinary Science, Gifu University, 1-1, Yanagido, Gifu, 501-1193, Japan; Department of Pre-Clinic and Applied Animal Science, Faculty of Veterinary Science, Mahidol University, Nakhon Pathom, 731170, Thailand.

Veterinary Microbiology
|December 30, 2018
PubMed

Insights

Feline morbillivirus (FeMV) infection is linked to kidney damage in cats. This study found FeMV antigens in tubular tissues, correlating with chronic kidney disease-like pathological changes.

Area of Science:

  • Veterinary Virology
  • Feline Pathology

Background:

  • Feline morbillivirus (FeMV), identified in 2012, is an emerging virus.
  • The pathogenicity of FeMV, particularly its role in feline kidney disease, remains unclear.

Purpose of the Study:

  • To investigate the association between FeMV infection and pathological alterations in feline kidney tissues.
  • To determine the localization of FeMV antigens within the kidneys and their correlation with tissue damage.

Main Methods:

  • Immunohistochemistry and immunofluorescent assays were employed to detect FeMV antigens in 38 feline kidney tissue samples.
  • Pathological changes in kidney tissues were analyzed and scored, with a focus on tubular and glomerular tissues.

Main Results:

  • FeMV antigens were predominantly localized in tubular tissues.
  • Significantly higher tissue injury scores, including interstitial cell infiltration, glomerulosclerosis, tubular atrophy, and fibrosis, were observed in FeMV-antigen-positive samples.
  • Feline IgG was detected in glomerular tissues, but no significant association or co-localization with FeMV antigens was found.

Conclusions:

  • This study confirms a link between FeMV infection and kidney tissue injury in cats.
  • FeMV infection contributes to pathological changes characteristic of chronic kidney disease in felines.
Keywords:
Chronic kidney diseasesFeMVFeline morbillivirusImmunohistochemistryPathogenicity

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