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Updated: Jan 31, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
Pleiotropic functions of plasmacytoid dendritic cells in the pathogenesis of the rheumatoid arthritis
Semyon V Kupriyanov1, Anton I Sinitskii1
1Department of Biochemistry, South-Ural State Medical University, Vorovskogo St., 64, Chelyabinsk 454092, Russia.
Abstract:
Rheumatoid arthritis is a chronic autoimmune inflammatory disease with an unclear etiology. The disease is characterized by infiltration of synovial tissue with immune cells, among which there are dendritic cells that play multifaceted roles in the pathogenesis of the disease. Here we shall assume that plasmacytoid dendritic cells are able to change their phenotype under the influence of various stimuli, thereby modulating the course of the disease, contributing to both the development of exacerbations and the induction of remissions depending on the phenotype they have acquired. This property can be used to develop new methods of immunotherapy.
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