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Updated: Jan 31, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
Published on: November 8, 2012
Sex difference in the effect of Internet gaming disorder on the brain functions: Evidence from resting-state fMRI
Min Wang1, Yanbo Hu2, Ziliang Wang1
1Department of Psychology, Zhejiang Normal University, Jinhua, PR China.
Objective:
Studies have shown that males are more prevalence than females in Internet gaming disorder (IGD). This study was set to explore the sex difference on the effect of IGD in resting states of the brain.
Methods:
Resting-state fMRI data were collected from 58 recreational Internet game users (RGU, male = 29) and 46 IGD subjects (male = 23). Regional homogeneity (ReHo) was used to calculate group difference between the subjects. A two-way ANOVA was used to explore the IGD-by-sex interactions. Correlations between addiction severity and the ReHo values were also calculated.
Results:
Significant sex-by-group interactions were found associated with the brain features in the right posterior cingulate (rPCC), left middle occipital gyrus (lMOG), right middle temporal gyrus (rMTG), and right postcentral gyrus (rPG). Post-hoc analysis revealed that comparing with same-sex RGUs, male IGD showed decreased ReHo in the rPCC, and the ReHo in the rPCC was also negatively associated with Internet addiction test (IAT) scores for male subjects. Moreover, male IGDs showed increased ReHo, but female ones showed decreased ReHo, in both lMOG and rMTG, when comparing with same-sex RGUs.
Conclusions:
Sex differences were observed in brain regions that are responsible for executive control, visual and auditory perception. These sex differences should be taken into consideration in future studies and the treatment of IGD.
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