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Bacterial cellulose graft versus fat graft in closure of tympanic membrane perforation

Yasser Mohammad Hassan Mandour1, Samira Mohammed2, M O Abdel Menem2

  • 1Faculty of Medicine, Department of Otorhinolaryngology, Benha University, Egypt.

American Journal of Otolaryngology
|December 31, 2018
PubMed
Abstract

Insights

Bacterial cellulose graft myringoplasty shows promising results for safe perforations, offering a simple, rapid, and safe surgical option with improved hearing and healing outcomes compared to fat or temporalis fascia grafts.

Area of Science:

  • Otolaryngology
  • Biomaterials Science
  • Regenerative Medicine

Background:

  • Myringoplasty is a surgical procedure to repair tympanic membrane perforations.
  • Autologous grafts like temporalis fascia and fat grafts are commonly used.
  • Novel biomaterials are being explored to improve surgical outcomes.

Purpose of the Study:

  • To compare the efficacy of bacterial cellulose graft myringoplasty with fat graft and temporalis fascia graft myringoplasty.
  • To evaluate graft success, hearing improvement, and surgical parameters.

Main Methods:

  • A prospective study involving 120 patients with mild to moderate safe tympanic membrane perforations.
  • Patients were randomized into three groups: bacterial cellulose graft, fat graft, and temporalis fascia graft (control).
  • Surgical outcomes including healing rates and hearing levels were assessed post-operatively.

Main Results:

  • Bacterial cellulose graft showed higher healing rates in both small (20/40) and moderate (17/40) perforations compared to fat graft (15/40 small, 10/40 moderate) and temporalis fascia graft (18/40 small, 12/40 moderate).
  • The bacterial cellulose group demonstrated better hearing outcomes.
  • Surgical time was shorter for bacterial cellulose graft myringoplasty.

Conclusions:

  • Bacterial cellulose graft myringoplasty is a viable, simple, and safe alternative for repairing mild to moderate tympanic membrane perforations.
  • It offers advantages in terms of faster healing, better hearing, and reduced surgical time.
  • This technique can be performed effectively under local anesthesia in an outpatient setting.
Keywords:
Bacterial cellulose graftFat graftHealingMyringoplasty

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