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Updated: Jan 31, 2026

Introduction to the Ultrasound Targeted Microbubble Destruction Technique
Published on: June 12, 2011
Ultrasound with Microbubble Contrast Agent and Urokinase for Thrombosis
Fangfang Wang1, Tiemei Shi1, Chang Su2
1Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Abstract:
This study was aimed at assessing the effects of urokinase (UK) in combination with ultrasound and microbubbles in in vitro and in vivo thrombolytic therapy for the treatment of deep vein thrombosis (DVT). Thrombi with formation times of 1, 3, 7, 14 and 21 d were used for thrombolysis. Forty-five adult mongrel dogs were used to evaluate thrombosis in vivo. Both in vitro and in vivo analyses revealed that UK + microbubbles had the best effect among the combinations. Thrombolysis <7 d was more effective at a thrombolysis rate of about 50%, but the thrombolytic effect of thrombi >7 d was poor at thrombolysis rates <30%. Ultrasound + UK significantly increased the thrombolysis rate of thrombi <7 d. These results suggest that the combination of ultrasound with microbubble contrast agents and UK may have a synergistic effect on thrombolysis.
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