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Phage-based vaccines.

Qing Bao1, Xiang Li1, Gaorong Han1

  • 1School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.

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|December 31, 2018
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Summary
This summary is machine-generated.

Bacteriophages (phages) are being explored as nanomedicine platforms for innovative vaccines. These phage-based vaccines, including displayed and DNA types, show promise for disease prevention and treatment.

Keywords:
BacteriophagePhage DNA vaccinePhage displayPhage displayed vaccineViruses

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Area of Science:

  • Virology
  • Immunology
  • Nanomedicine

Background:

  • Bacteriophages (phages) are viruses that infect bacteria.
  • Phages are composed of nucleic acids and proteins, forming a capsid.
  • In eukaryotes, phages act as inert antigens, incapable of causing disease.

Purpose of the Study:

  • To review recent advancements in phage-based vaccines.
  • To explore applications of phage-based vaccines in disease prevention and treatment.
  • To discuss challenges and future perspectives in the field of phage-based vaccines.

Main Methods:

  • Utilizing whole phage particles for vaccine design.
  • Developing phage-displayed vaccines with antigens on the phage surface.
  • Creating phage DNA vaccines by inserting vaccine genes into phage genomes.

Main Results:

  • Phage-displayed vaccines present antigens via genetic display, chemical conjugation, or biological binding.
  • Phage DNA vaccines deliver genes to target cells for antigen expression.
  • Both vaccine types can elicit immune responses for disease prevention and treatment.

Conclusions:

  • Phage-based vaccines, including displayed and DNA types, offer a promising future for vaccine development.
  • Recent advancements highlight the potential of phages as versatile nanomedicine platforms.
  • Further research and development are crucial to overcome challenges and advance phage-based vaccine technology.