Related Experiment Video
Updated: Jan 31, 2026
05:54
Real-Time Dynamic Navigation System for the Precise Quad-Zygomatic Implant Placement in a Patient with a Severely Atrophic Maxilla
Published on: October 18, 2021
2.3K
Occurrence of significant long PR intervals in patients implanted for sinus node dysfunction and monitored with
Jérôme Taieb1, Pierre Le Franc2, Pierre Khattar3
1Service de cardiologie, centre hospitalier du Pays-d'Aix, avenue des Tamaris, 13616 Aix-en-Provence, France.
Archives of Cardiovascular Diseases
|December 31, 2018
Summary
Nearly half of patients with sinus node dysfunction developed long PR intervals after pacemaker implantation. Amiodarone use predicted these intervals, which trended towards an association with new atrial fibrillation.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Device Technology
Background:
- Long PR intervals are associated with increased cardiovascular complications, including atrial fibrillation.
- Pacemaker SafeR™ mode monitors PR intervals, switching from AAI to DDD pacing if atrioventricular block criteria are met.
Purpose of the Study:
- To evaluate the incidence and predictors of long PR intervals (LPRIs) in patients with sinus node dysfunction (SND).
- To assess the association between LPRIs and incident atrial fibrillation (AF) after one year.
- To identify baseline predictors of LPRIs in patients without baseline conduction disorders.
Main Methods:
- Prospective, multicentre, observational trial (PRECISE study) in France.
- 214 patients with SND implanted with REPLY™ dual-chamber pacemakers, free from baseline conduction disorders.
- Pacemaker data analyzed for LPRIs (≥350/450ms consecutive PR/AR intervals) and AF (mode switch >1 min/day); logistic regression used for predictor analysis.
Main Results:
- After one year, 116 patients (54%) experienced LPRIs, and 63 patients (30%) developed AF.
- Amiodarone was the sole independent predictor of LPRIs (OR 2.50, 95% CI 1.20-5.21, P=0.014).
- A significant trend was observed between LPRIs and incident AF (OR 1.86, 95% CI 0.97-3.61, P=0.051).
Conclusions:
- Approximately half of patients with SND develop LPRIs within a year post-pacemaker implantation.
- Amiodarone is identified as the only independent predictor for developing LPRIs.
- A strong association trend exists between LPRIs and the incidence of atrial fibrillation.
Related Concept Videos
01:03Prediction Intervals
3.4K
The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
3.4K
01:21Types of Reports II: Incident or Occurrence Report
1.3K
An Incident or Occurrence Report in a healthcare setting is a crucial document used to record any unexpected occurrence that may or may not have affected a patient, employee, or visitor. Such reports are critical to improving patient safety and include all details leading up to and including the event.
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...
1.3K
01:21Confidence Intervals
10.7K
An unbiased point estimate is often insufficient to predict a population estimate, such as population mean or population proportion. In this scenario, a confidence interval is used. A confidence interval is an estimate similar to a sample proportion. However, unlike the point estimate which is a single value, the confidence interval contains a range of values. These values have lower and upper limits, known as confidence limits, and can be designated as L1 and L2, respectively.
A...
A...
10.7K
01:29Improper Integrals: Infinite Intervals
98
An integral is classified as improper due to an infinite interval when at least one of its limits of integration extends to positive or negative infinity. In such cases, the region under the curve is unbounded, and standard techniques for evaluating definite integrals are not directly applicable. Instead, the improper integral is defined through a limiting process that allows one to determine whether the accumulated area remains finite despite the infinite domain.Application to Exponential...
98
03:37Uncertainty in Measurement: Accuracy and Precision
101.1K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value.
101.1K
01:16ECG Interpretation of Arrhythmias I: Sinus Arrhythmias
826
Arrhythmias are disturbances in the heart's rhythm that lead to abnormal heartbeats. These irregularities can originate from different parts of the heart and are classified based on their origin and nature.
Types of Arrhythmias
Sinus Node Arrhythmias
Sinus Bradycardia: Originating from the sinoatrial (SA) node, sinus bradycardia involves slower impulses, resulting in a heart rate of less than 60 beats per minute (bpm). Causes include sleep, vagal stimulation, beta-blockers, hypothyroidism,...
Types of Arrhythmias
Sinus Node Arrhythmias
Sinus Bradycardia: Originating from the sinoatrial (SA) node, sinus bradycardia involves slower impulses, resulting in a heart rate of less than 60 beats per minute (bpm). Causes include sleep, vagal stimulation, beta-blockers, hypothyroidism,...
826