Effect of gender-related depression on heart rate variability during an autonomic nervous test

Patients with depression have lower heart rate variability (HRV) compared with controls. However, studies have indicated HRV difference between male and female controls. The gender effect might be interactive with the depression effect on the HRV, resulting in a low accuracy of recognising the patients with depression from the controls. Our study explores the effect of gender-related depression on HRV. Four ANS tests including resting, deep breathing, Valsalva, and orthostatic test are employed as stimuli. HRV were collected from 182 subjects comprising 91 depressive patients (33 females/58 males) and 91 controls (33 females/58 males) in the four tests. Time and frequency domains and nonlinear parameters are employed to quantify HRV. Two-way ANOVA is applied to evaluate the effect of gender-related depression. Most HRV parameters of the patients significantly differ from those of the controls, but some parameters indicate different depression effect between the males and females in the deep breathing and Valsalva test. Some HRV parameters illustrate significant difference between the male and female controls. Therefore, the effect of depression on HRV of each gender should be investigated.