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Published on: September 13, 2014
Neonatal Acute Liver Failure Associated with Angioinvasive Hepatic Zygomycosis
Suvradeep Mitra1, Somosri Ray2, Gurwinder Kaur1
1a Department of Histopathology , Post Graduate Institute of Medical Education and Research , Chandigarh , India.
Background:
Neonatal acute liver failure (NALF) is often a fatal condition. Zygomycosis is a fungal infection that is often fatal in both adults and infants. Only a few cases of hepatic zygomycosis are reported in the literature and they are invariably associated with immunosuppression.
Materials And Methods:
Post-mortem liver biopsy from a 14-day old neonate demonstrated confluent panacinar necrosis with angioinvasive zygomycosis. The limited work-up could not rule out an underlying immunodeficiency.
Conclusion:
Angioinvasive hepatic zygomycosis can present in the neonatal period as NALF.
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