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Thrombospondin 1 Is Increased in the Aorta and Plasma of Patients With Acute Aortic Dissection

Tao Zeng1, Jun Yuan1, Jianting Gan1

  • 1Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.

The Canadian Journal of Cardiology
|January 1, 2019
PubMed

Insights

Thrombospondin 1 (TSP-1) is significantly elevated in human aortic dissection (AD) patients. Increased TSP-1 may contribute to AD by promoting macrophage activation and smooth muscle cell apoptosis.

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Pathophysiology

Background:

  • Thrombospondin 1 (TSP-1) is implicated in cardiovascular diseases like atherosclerosis.
  • TSP-1's role and expression in human aortic dissection (AD) remain uncharacterized.

Purpose of the Study:

  • To investigate TSP-1 expression levels in human aortic dissection (AD).
  • To explore the correlation between TSP-1 and other inflammatory markers in AD.
  • To determine the functional impact of TSP-1 on macrophage and smooth muscle cell behavior.

Main Methods:

  • TSP-1 levels were quantified in aortic tissues from AD patients and controls.
  • Plasma levels of TSP-1, IL-6, MMP-2, and MMP-9 were measured in AD and non-AD patients.
  • In vitro experiments assessed the effects of recombinant TSP-1 on macrophages and smooth muscle cells.

Main Results:

  • Aortic TSP-1 expression was significantly higher in AD patients, particularly in dissected areas.
  • Plasma TSP-1, IL-6, MMP-2, and MMP-9 levels were elevated in AD patients and correlated positively.
  • TSP-1 independently correlated with AD onset and promoted M1 macrophage differentiation and SMC apoptosis in vitro.

Conclusions:

  • TSP-1 levels are significantly increased in human aortic dissection.
  • Elevated TSP-1 may contribute to AD pathogenesis by influencing macrophage activation and smooth muscle cell apoptosis.
Abstract

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