Related Experiment Video

Updated: Jan 31, 2026

Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation
05:42

Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation

Published on: October 25, 2024

1.6K

Evaluation of SERENE-CAG score for assessing suitability for coronary angiography preoperatively in patients

Kamal Sharma1, Roopesh Singhal1, Nikhil Jadhav1

  • 1Department of Cardiology, U. N. Mehta Institute of Cardiology and Research Centre, Civil Hospital Campus, Ahmedabad- 380016, Gujarat, India.

Indian Heart Journal
|January 1, 2019
PubMed

Insights

A new SERENE-CAG score helps select rheumatic heart disease patients for coronary angiography, reducing unnecessary procedures and improving patient selection for invasive coronary angiograms.

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Diagnostic Imaging

Background:

  • Rheumatic heart disease (RHD) patients often require assessment for coronary artery disease (CAD) before valve surgery.
  • Current selection criteria for preoperative coronary angiography (CAG) in RHD patients may not be optimal.

Purpose of the Study:

  • To develop and validate an indigenous scoring system, SERENE-CAG (Selecting Patients Of Rheumatic Heart Disease Undergoing Valve Surgery For Presurgical Coronary Angiography), to improve selection for preoperative CAG in RHD patients.
  • To identify better selection criteria for preoperative CAG in RHD patients.

Main Methods:

  • A prospective study of 798 RHD patients undergoing preoperative CAG from January 2016 to December 2017.
  • Multivariate logistic regression analysis was used to identify significant predictors of CAD.
  • An additive score (SERENE-CAG score) was developed based on significant variables.

Main Results:

  • The prevalence of significant CAD requiring revascularization in RHD patients was 6.26% (50 patients).
  • Male gender was a significant predictor of CAD (odds ratio 2.6).
  • A SERENE-CAG score threshold of >2.8 demonstrated 80% sensitivity and 36.9% specificity for predicting CAD, with a negative predictive value of 96.5%.

Conclusions:

  • The prevalence of CAD in RHD patients undergoing valve surgery is low.
  • The SERENE-CAG score can help optimize patient selection for CAG, potentially deferring 34.6% of normal angiograms.
  • Exploring noninvasive CAD screening modalities and refining patient selection can minimize risks associated with invasive procedures.
Abstract

Keywords:
Coronary angiographyCoronary artery diseaseValvular heart disease

More Related Videos

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

11.9K
Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement14:14

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

14.7K

Related Concept Videos

Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
574
Introduction to z Scores01:06

Introduction to z Scores

A z score (or standardized value) is measured in units of the standard deviation. It tells you how many standard deviations the value x is above (to the right of) or below (to the left of) the mean, μ. Values of x that are larger than the mean have positive z scores, and values of x that are smaller than the mean have negative z scores. If x equals the mean, then x has a zero z score. It is important to note that the mean of the z scores is zero, and the standard deviation is one.
z scores...
11.2K
Introduction to z Scores01:05

Introduction to z Scores

A z score (or standardized value) is measured in units of the standard deviation. It indicates how many standard deviations the value x is above (to the right of) or below (to the left of) the mean, μ. Values of x that are larger than the mean have positive z scores, and values of x that are smaller than the mean have negative z scores. If x equals the mean, then x has a zero z score. It is important to note that the mean of the z scores is zero, and the standard deviation is one.
z scores...
1.3K
z Scores and Area Under the Curve01:17

z Scores and Area Under the Curve

z scores are the standardized values obtained after converting a normal distribution into a standard normal distribution. A z score is measured in units of the standard deviation. The z score tells you how many standard deviations the value x is above (to the right of) or below (to the left of) the mean, μ. Values of x that are larger than the mean have positive z scores, and values of x that are smaller than the mean have negative z scores. If x equals the mean, then x has a z score of...
19.6K
Heart Valves01:16

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
12.1K
Coronary Circulation01:21

Coronary Circulation

The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
7.2K