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Clinical, demographic, risk factor and angiographic profile of coronary slow flow phenomenon: A single centre
Sanjeev Sanghvi1, Rohit Mathur1, Anil Baroopal1
1Department of Cardiology, DR. S.N. Medical College, Jodhpur, India.
Insights
The coronary slow flow phenomenon (CSFP) is linked to hypertension, dyslipidemia, and tobacco use. These risk factors are independently associated with CSFP, indicating it
Area of Science:
- Cardiology
- Interventional Cardiology
- Coronary Artery Disease
Background:
- Coronary slow flow phenomenon (CSFP) is an angiographic finding of delayed distal vessel opacification without significant stenosis.
- The exact causes of CSFP remain unclear despite being known for decades.
Purpose of the Study:
- To determine the clinical, demographic, risk factor, and angiographic profile of patients with CSFP.
- To identify factors associated with the development of CSFP.
Main Methods:
- Consecutive patients undergoing coronary angiography between September 2016 and March 2017 were analyzed.
- Patients with CSFP were compared to a control group with normal coronary flow (NCF).
- CSFP diagnosis was based on the corrected thrombolysis in myocardial infarction frame count.
Main Results:
- CSFP was more prevalent in males.
- Hypertension, dyslipidemia, and tobacco use were significantly more common in CSFP patients.
- Multivariable analysis revealed hypertension, dyslipidemia, smoking, and tobacco chewing as independent risk factors for CSFP.
- Acute coronary syndrome (ACS) was the most frequent presentation in CSFP patients.
Conclusions:
- CSFP is common in patients presenting with ACS.
- Hypertension, dyslipidemia, smoking, and tobacco chewing are independent risk factors for CSFP.
- CSFP should be regarded as a pathological entity, not a benign condition.
Background:
The coronary slow flow phenomenon (CSFP) is an angiographic finding characterized by delayed distal vessel opacification in the absence of significant epicardial coronary stenosis. Although it is well-known to interventional cardiologists for approximately four decades, the etiopathogenesis still remains unclear.
Aims And Objectives:
In this study, we aimed to determine the clinical, demographic, risk factor and angiographic profile of patients with CSFP.
Methods:
Clinical, demographic, risk factor and angiographic profile were recorded in all consecutive patients who had undergone coronary angiography between September 2016 and March 2017 and showed features of CSFP and a control group who showed normal coronary flow (NCF). The CSFP was diagnosed on the basis of the corrected thrombolysis in myocardial infarction frame count.
Results:
CSFP was significantly more prevalent in male patients. Among the traditional risk factors, there was significantly more prevalence of hypertension (31.25% versus 6.67%, p < 0.001), dyslipidemia (40% versus 7.5%, p < 0.001) and history of tobacco use (47.5% versus 10.0%, p < 0.001) in CSFP patients as compared to NCF patients. On multivariable regression analysis hypertension, dyslipidemia, history of smoking and tobacco chewing were found to have independent association with CSFP. Acute coronary syndrome (ACS) was the most common mode of presentation in CSFP patients.
Conclusion:
CSFP was relatively common among patients who presented with ACS. Hypertension, dyslipidemia, smoking and tobacco chewing can be considered independent risk factors for this phenomenon. Therefore, CSFP should be considered as a pathological entity and not an entirely benign condition.
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