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To study the effect of high dose Atorvastatin 40mg versus 80mg in patients with dyslipidemia

Deepak Agrawal1, S C Manchanda2, J P S Sawhney3

  • 1Department of Cardiology, Sir Ganga Ram hospital, 13/4, Upper ground floor, West Patel Nagar, New Delhi, 110008, India.

Indian Heart Journal
|January 1, 2019
PubMed

Insights

This study found that both 40mg and 80mg doses of atorvastatin are equally effective for treating atherosclerotic dyslipidemia in Indian patients. However, the higher 80mg dose was associated with a greater incidence of myalgia.

Area of Science:

  • Cardiology
  • Pharmacology
  • Metabolic Diseases

Background:

  • Atherosclerotic dyslipidemia is a significant risk factor for cardiovascular disease.
  • Statins, like atorvastatin, are cornerstone therapies for managing dyslipidemia.
  • Optimal dosing strategies for atorvastatin in diverse populations require ongoing investigation.

Purpose of the Study:

  • To compare the efficacy and safety of atorvastatin 40mg versus 80mg in Indian patients with atherosclerotic dyslipidemia.
  • To evaluate the impact of different atorvastatin doses on LDL-C, HDL-C, and triglycerides.
  • To assess the incidence of side effects, including myopathy, hepatotoxicity, and new-onset diabetes mellitus, for each atorvastatin dose.

Main Methods:

  • A prospective, randomized, open-label, comparative study involving 240 Indian patients diagnosed with dyslipidemia.
  • Patients were divided into two groups: Group A received atorvastatin 40mg daily, and Group B received atorvastatin 80mg daily.
  • A 6-month follow-up period was utilized to assess lipid profiles and adverse events.

Main Results:

  • Both atorvastatin 40mg and 80mg demonstrated significant reductions in LDL cholesterol at 3 and 6 months.
  • No statistically significant difference was observed in LDL-C reduction between the 40mg and 80mg groups at either time point (p=.118 & p=.149).
  • A higher incidence of myalgia was reported in the 80mg group (7 patients) compared to the 40mg group (2 patients), with a significant difference (p=.045). No significant CPK elevation was noted.

Conclusions:

  • Atorvastatin 40mg and 80mg are equally effective in improving lipid profiles for atherosclerotic dyslipidemia in the studied Indian population.
  • The higher dose of atorvastatin (80mg) is associated with an increased risk of myalgia.
  • These findings suggest a need for individualized dosing strategies to balance efficacy and tolerability.
Abstract

Keywords:
AtherosclerosisAtorvastatinDyslipidemiaMyalgia

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