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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
Published on: May 31, 2016
A strong and reliable indicator for early postoperative major cardiac events after elective orthopedic surgery:
Adem Adar1, Orhan Onalan1, Fahri Cakan1
1Karabuk University Faculty of Medicine, Department of Cardiology, Karabuk, Turkey.
Insights
Aortic arch calcification predicts major cardiac events after orthopedic surgery. This finding helps identify patients at higher risk for cardiovascular complications, improving patient outcomes.
Area of Science:
- Cardiology
- Orthopedic Surgery
- Radiology
Background:
- Cardiovascular events pose a mortality risk following orthopedic surgery.
- Predicting early cardiovascular events is crucial for patient safety.
Purpose of the Study:
- To examine the association between aortic arch calcification and 30-day major adverse cardiac events (MACE) after elective orthopedic surgery.
Main Methods:
- 714 patients undergoing elective orthopedic surgery were analyzed.
- Preoperative assessments included medical history, echocardiography, and chest X-ray.
- Aortic arch calcification was graded from chest X-rays; patients were monitored for 30-day MACE.
Main Results:
- 33 patients experienced MACE.
- Aortic arch calcification, smoking, and hypertension were independent predictors of MACE.
- Patients with MACE had higher prevalence of aortic arch calcification, coronary artery disease, hypertension, and smoking.
Conclusions:
- Aortic arch calcification is a significant predictor of 30-day MACE in patients undergoing elective orthopedic surgery.
- Identifying aortic arch calcification can aid in risk stratification for cardiovascular events.
Background:
Cardiovascular events after orthopedic surgery may result in mortality. Therefore, predictors of early cardiovascular events after elective orthopedic surgery are required.
Aim:
The aim of this study is to investigate the relationship between aortic arch calcification and 30-day major adverse cardiac events following elective orthopedic surgery.
Methods:
Patients who had undergone orthopedic surgery were screened. Preoperative detailed anamnesis was taken. Echocardiography and standard chest x-ray were performed.Patients were followed in terms of perioperative 30-days major cardiac events and were classified into two groups according to development of perioperative major adverse cardiac events.Aortic arch calcification was evaluated by two cardiologists, blinded to study findings and was graded as 0 to 3 on chest x-ray.
Results:
A total of 1060 patients were approached for the study participation. Of these 714 were included in the study (mean age: 70.43, 65% female). Cardiovascular events occurred in 33 patients. As compared to the patients without cardiac events, the prevalence of aortic arch calcification, coronary artery disease, hypertension, and smoking were higher in patients with cardiac events. In addition, Lee index, left ventricular end-systolic, end-diastolic and left atrial diameter were significantly higher, GFR values were significantly lower in the group with cardiac events.Multivariate regression analysis showed that smoking (OR 5.031, 95% CI 1.602 to 15.794), presence of hypertension (OR 5.133, 95% CI 1.297 to 20.308) and aortic arch calcification (OR 6.920, 95% CI 3.890 to 12.310) are independent predictors of major cardiac events within 30-day of elective orthopedic surgery.
Conclusions:
Presence of aortic arch calcification is associated with development of major cardiac events within 30-days after elective orthopedic surgery.
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A titration is carried out for 25.00 mL of 0.100 M HCl (strong acid) with 0.100 M of a strong base NaOH. The pH at different volumes of added base solution can be calculated as follows:
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