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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
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Insulin-Like Growth Factor-1 in Acute Ischemic Stroke
Hala Shaheen1, Sayed Sobhy1, Sherine El Mously1
1Faculty of Medicine, Fayoum University, Keman Fares area, Fayoum City, 63611 Egypt.
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
|January 1, 2019
Summary
Low serum insulin-like growth factor-1 (IGF-1) levels are linked to a higher risk of acute ischemic stroke (AIS) in Egyptians. Lower IGF-1 is an independent risk factor for stroke occurrence.
Area of Science:
- Neuroscience
- Endocrinology
- Epidemiology
Background:
- Cerebrovascular ischemic stroke is a leading cause of mortality and disability worldwide.
- Insulin-like growth factor-1 (IGF-1) demonstrates neuroprotective properties against ischemic brain injury.
Purpose of the Study:
- To investigate the association between serum IGF-1 levels and acute ischemic stroke (AIS) in the Egyptian population.
- To determine if IGF-1 levels are an independent risk factor for AIS.
Main Methods:
- A case-control study involving 200 patients with AIS and 100 healthy controls.
- Neurological examination, NIH Stroke Scale (NIHSS) assessment, and serum IGF-1 level measurement were performed.
- Controls were matched for age, gender, and vascular risk factors.
Main Results:
- Serum IGF-1 levels were significantly lower in AIS patients compared to controls.
- Reduced serum IGF-1 (< 148.3 ng/ml) was identified as an independent risk factor for AIS.
- This association remained significant after adjusting for conventional vascular risk factors.
Conclusions:
- Lower serum IGF-1 levels are significantly associated with an increased risk of ischemic stroke in the Egyptian population.
- IGF-1 may serve as a potential biomarker for stroke risk assessment.
- Findings highlight the role of IGF-1 in cerebrovascular health.
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