Hepatitis C Virus Induced Sjogren Syndrome - Clinical and Imaging Features

Area of Science:

• Neurology
• Genetics

Background:

• Charcot-Marie-Tooth (CMT) is the most prevalent inherited neurological disorder, currently without a cure.
• The primary genetic cause of CMT is a PMP22 gene duplication on chromosome 17.
• CMT affects a small but significant portion of the population.

Purpose of the Study:

• To report a case of a 37-year-old male diagnosed with Charcot-Marie-Tooth disease.
• To describe the patient's co-occurring sleep, memory, and attention disorders, including early-onset retrograde amnesia.
• To explore potential links between CMT, diabetes mellitus, and associated complications.

Main Methods:

• Case report of a 37-year-old male patient.
• Clinical assessment of neurological and cognitive symptoms.
• Review of patient's medical history, including diagnosis of diabetes mellitus.

Main Results:

• The patient presented with Charcot-Marie-Tooth disease.
• He exhibited sleep disturbances, memory deficits, and attention problems, notably early retrograde amnesia.
• The patient had a history of diabetes mellitus, which correlated with sensory loss and prolonged infections.

Conclusions:

• Charcot-Marie-Tooth disease can present with significant cognitive and sleep-related symptoms beyond typical motor and sensory deficits.
• Diabetes mellitus may exacerbate sensory symptoms and increase susceptibility to infections in CMT patients.
• This case underscores the complex and multifaceted nature of CMT and its potential systemic implications.