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Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
P53 Immunoexpression in Laryngeal Squamous Cell Carcinoma
Liliana Cercelaru1, A E Stepan1, C Mărgăritescu1
1Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania.
Abstract:
p53 is a marker described in the premalignant lesions with a high risk of malignant transformation for laryngeal cancer. It is a tumor suppressor gene that during the cancer gains also oncogenic activity. We aimed to study the p53 immunoexpression in 38 cases of laryngeal squamous cell carcinomas and the relation with the clinicopathological aspects. We obtained variable p53 expression regarding the differentiation degree and tumor stage. The higher p53 immunotaining values were observed in high grade and advanced stages lesions. P53 may be useful in identifying aggresive laryngeal squamous carcinomas, a useful aspect for better stratification of patients for therapy.
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