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Updated: Jan 31, 2026
03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
839
EGFR Immunoexpression in Laryngeal Squamous Cell Carcinoma
Liliana Cercelaru1, A E Stepan1, C Mărgăritescu1
1Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania.
Current Health Sciences Journal
|January 1, 2019
Summary
High epidermal growth factor receptor (EGFR) expression indicates aggressive laryngeal squamous cell carcinomas. This finding suggests EGFR may help identify tumors with poor prognosis.
Area of Science:
- Oncology
- Molecular Biology
Background:
- Epidermal growth factor receptor (EGFR) is a tyrosine kinase crucial in early neoplastic transformation.
- Elevated EGFR expression correlates with aggressive tumor behavior, metastasis, and treatment resistance.
Purpose of the Study:
- To investigate the immunohistochemical expression of EGFR in laryngeal squamous cell carcinomas.
- To correlate EGFR expression with clinicopathological prognostic parameters.
Main Methods:
- Analysis of EGFR immunohistochemical expression in 38 cases of laryngeal squamous cell carcinomas.
- Correlation of EGFR immunoreactions with tumor grade and stage.
Main Results:
- EGFR immunoreactions were significantly higher in high-grade laryngeal carcinomas.
- While EGFR values trended higher in advanced stages, this association was not statistically significant.
Conclusions:
- EGFR expression is significantly associated with high-grade laryngeal squamous cell carcinomas.
- EGFR may serve as a valuable biomarker for identifying aggressive laryngeal cancers.
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