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Updated: Jan 31, 2026

Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis
Published on: October 12, 2016
Case Presentation of Soft Tissue Defect after Bimalleolar Fracture Osteosynthesis.
A Grecu1, O Nica2, Daniela Marinescu3
1Department of Orthopaedics and Traumatology, Clinical Emergency County Hospital of Craiova; PhD Student at University of Medicine and Pharmacy of Craiova.
This case study highlights successful wound healing for a complex ankle fracture complication. Advanced treatments like negative-pressure wound therapy and platelet-rich plasma therapy aided recovery.
Area of Science:
- Orthopedic Surgery
- Plastic and Reconstructive Surgery
- Wound Healing Research
Background:
- A 59-year-old patient presented with severe right ankle wound dehiscence and skin necrosis post-osteosynthesis for a bimalleolar fracture.
- The initial open reduction and internal fixation with plate and screws, performed abroad, led to a critical surgical site complication within 16 days.
Purpose of the Study:
- To document the management and successful outcome of a complex post-operative wound complication involving skin necrosis and dehiscence.
- To evaluate the efficacy of a multi-modal treatment approach including surgical debridement, negative-pressure wound therapy, and platelet-rich plasma therapy.
Main Methods:
- Initial surgical debridement of necrotic tissue was performed.
- Post-operative management included Negative-pressure wound therapy (VAC dressing) and Platelet-rich plasma (PRP) therapy.
- A sural fasciocutaneous flap was utilized to cover the resultant skin defect after granulation tissue formation.
Main Results:
- The patient's wound showed granulation tissue formation without signs of infection after initial debridement and advanced therapies.
- The sural fasciocutaneous flap demonstrated proper graft integration.
- Complete healing of the complex ankle wound was achieved.
Conclusions:
- A combination of surgical debridement, Negative-pressure wound therapy, and Platelet-rich plasma therapy can effectively manage severe post-operative wound complications.
- Fasciocutaneous flap coverage is a viable reconstructive option for significant skin defects following osteosynthesis complications.
- This case underscores the importance of timely and aggressive multi-modal treatment in achieving favorable outcomes for complex wound healing challenges.
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