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Stem cell therapy for patients with diabetes: a systematic review and meta-analysis of metabolomics-based risks and

Fakher Rahim1,2, Babak Arjmand3, Kiarash Shirbandi4

  • 1Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Stem Cell Investigation
|January 1, 2019
PubMed
Abstract

Insights

Stem cell therapy shows potential benefits for diabetes patients, improving key health markers. However, careful consideration of risks, including potential cancer formation, is crucial before widespread adoption.

Area of Science:

  • Regenerative Medicine
  • Endocrinology
  • Clinical Research

Background:

  • Stem cell therapy offers a promising avenue for treating diabetes.
  • Understanding the risks and benefits is essential for developing effective therapeutic strategies.
  • A balanced risk-benefit profile is key to advancing novel diabetes treatments.

Purpose of the Study:

  • To systematically review and analyze clinical trials on stem cell therapy for diabetes (T1DM and T2DM).
  • To determine the overall benefits and risks associated with this therapeutic approach.

Main Methods:

  • Conducted a systematic review and meta-analysis of all available clinical trials.
  • Performed an extensive literature search across multiple databases using relevant MeSH terms for stem cell therapy and diabetes.

Main Results:

  • In Type 2 Diabetes Mellitus (T2DM), stem cell therapy improved insulin requirements and HbA1C but negatively impacted c-peptide.
  • In Type 1 Diabetes Mellitus (T1DM), it enhanced c-peptide and HbA1C levels but negatively affected insulin requirements.
  • Stem cells possess self-renewal and differentiation capabilities but carry a paradoxical risk of cancer formation.

Conclusions:

  • Stem cell therapy presents a complex risk-benefit profile for diabetes management.
  • The potential for cancer formation necessitates caution among healthcare providers and patients.
  • Further research prioritizing risk-benefit assessment is critical for advancing stem cell therapy in diabetes treatment.
Keywords:
Type 2 diabetes mellitus (T2DM)glycosylated hemoglobin (HbA1C)stem cellstype 1 diabetes mellitus (T1DM)

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