Related Experiment Video

Updated: Jan 31, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.8K

There Is No Impact of Diabetes on the Endothelial Function of Chronic Kidney Disease Patients

Mariana Nogueira Coutinho1, Aluizio Barbosa Carvalho1, Maria Aparecida Dalboni1

  • 1Federal University of São Paulo, Brazil.

Journal of Diabetes Research
|January 1, 2019
PubMed

Insights

Diabetes does not worsen endothelial dysfunction in chronic kidney disease (CKD) patients. Uremia appears to be the primary driver of endothelial dysfunction in these individuals, regardless of diabetes status.

Area of Science:

  • Nephrology
  • Cardiology
  • Endocrinology

Background:

  • Patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (DM) face elevated risks of endothelial dysfunction, cardiovascular disease, and mortality.
  • Existing research often examines these conditions separately, leaving a gap in understanding their combined impact on endothelial function.
  • This study addresses the scarcity of data on patients with both CKD and DM.

Purpose of the Study:

  • To investigate the additional effect of type 2 diabetes mellitus (DM) on endothelial dysfunction in patients with chronic kidney disease (CKD).
  • To compare markers of endothelial function between CKD patients with and without DM.

Main Methods:

  • A comparative study involving 74 patients: 37 with CKD and DM (CKD-DM group) and 37 with CKD alone (CKD group).
  • Measurements included endothelial progenitor cells (EPCs), stromal-derived factor 1 alpha (SDF-1α), nitric oxide (NO) levels (serum and urinary), flow-mediated dilation (FMD), and pulse wave velocity (PWV).

Main Results:

  • The CKD-DM group exhibited a higher prevalence of obesity, prior myocardial infarction, myocardial revascularization, and a trend towards more peripheral artery disease.
  • Significantly higher levels of EPCs and PWV were observed in the CKD-DM group compared to the CKD group.
  • No significant differences were found in SDF-1α, serum/urinary NO, or FMD between the two groups.

Conclusions:

  • Endothelial dysfunction is a common issue in CKD patients.
  • The presence of diabetes does not appear to additively worsen endothelial dysfunction in CKD patients.
  • Uremia is suggested as the predominant factor contributing to endothelial dysfunction in this patient population.
Abstract

More Related Videos

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice10:43

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice

Published on: October 31, 2007

28.8K
Assessment of Kidney Function in Mouse Models of Glomerular Disease09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

18.6K

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
728
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
650
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
468
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
392
Chronic Obstructive Pulmonary Disease01:24

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.5K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
4.5K