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Eicosanoids and platelet activating factor mechanisms in organ rejection
1Department of Surgery, Georgetown University Medical Center, Washington, DC 20007.
Transplantation Proceedings
|December 1, 1988
Summary
Eicosanoids and platelet-activating factor (PAF) impact immune responses. Prostaglandins (PG) may weaken cell-mediated immunity, while thromboxanes (TX), leukotrienes (LT), and PAF may enhance it.
Area of Science:
- Immunology
- Biochemistry
- Pharmacology
Background:
- Eicosanoids and platelet-activating factor (PAF) are bioactive lipids involved in inflammatory and immune processes.
- Their precise roles in modulating cell-mediated immune responses and transplant rejection are complex and require further elucidation.
Purpose of the Study:
- To summarize the modulatory effects of eicosanoids and PAF on immune responses.
- To differentiate the roles of various eicosanoids (prostaglandins, thromboxanes, leukotrienes) and PAF in cell-mediated immunity.
Main Methods:
- In vitro and in vivo studies were reviewed.
- The effects of prostaglandins (PG), thromboxanes (TX), leukotrienes (LT), and PAF on immune cells and processes were analyzed.
Main Results:
- Eicosanoids and PAF were found to modulate immune responses both in vitro and in vivo.
- PG appear to attenuate cell-mediated immune responses.
- TX, LT, and PAF seem to potentiate cell-mediated immune responses.
Conclusions:
- Eicosanoids and PAF play significant roles in regulating immune responses.
- Specific eicosanoids have opposing effects on cell-mediated immunity.
- These compounds also exert non-immunologic effects influencing transplant rejection, such as edema and reduced blood flow.