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Related Concept Videos

What are Cells?01:07

What are Cells?

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Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
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What are Cells?01:15

What are Cells?

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Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium, or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
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What is Cell Signaling?02:03

What is Cell Signaling?

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Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
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Concentration Cells02:41

Concentration Cells

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A concentration cell is a type of a  voltaic cell constructed by connecting two almost identical half-cells, both based on the same half-reaction and using the same electrode, differing only in the concentration of one redox species. A concentration cell's potential, therefore, is determined only by the concentration difference of the particular redox species.
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Chemistry of the Cell02:58

Chemistry of the Cell

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The cell is chemically composed of water, organic molecules and inorganic ions.
Water
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Hair Cells01:22

Hair Cells

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Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
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Related Experiment Video

Updated: Jan 31, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

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Hepatosplenic T-Cell Lymphomas.

Lohith Gowda1, Francine Foss2

  • 1Hematology and Bone Marrow Transplantation, Yale University School of Medicine, New Haven, CT, USA.

Cancer Treatment and Research
|January 1, 2019
PubMed
Summary
This summary is machine-generated.

Hepatosplenic T-cell lymphoma (HSTL) is a rare, aggressive cancer primarily affecting young men. Current treatments offer limited success, highlighting the urgent need for novel therapeutic strategies.

Keywords:
Genomic landscapeHepatosplenic T-cell lymphomaImmunosuppressionStem cell transplantation

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Area of Science:

  • Oncology
  • Hematology
  • Immunology

Background:

  • Hepatosplenic T-cell lymphoma (HSTL) is a rare, aggressive extranodal peripheral T-cell lymphoma (PTCL).
  • It predominantly affects young men and is linked to immune dysregulation and immunosuppression.
  • Clinical features include hepatosplenomegaly, fever, weakness, and potential cytopenias due to organ involvement.

Purpose of the Study:

  • To review the current understanding of Hepatosplenic T-cell lymphoma.
  • To highlight the challenges in diagnosis and treatment.
  • To emphasize the need for novel therapeutic approaches.

Main Methods:

  • Literature review of Hepatosplenic T-cell lymphoma.
  • Analysis of disease presentation, pathogenesis, and treatment outcomes.
  • Discussion of current therapeutic limitations and future directions.

Main Results:

  • HSTL is associated with poor prognosis and high mortality rates.
  • Anthracycline-based chemotherapy provides only modest responses.
  • Hematopoietic stem cell transplant (HSCT) is an option for eligible patients but relapse is common.

Conclusions:

  • Hepatosplenic T-cell lymphoma requires further investigation into its biology.
  • Mechanistic-driven drug discovery is crucial to overcome current therapeutic limitations.
  • Improved treatment strategies are needed for this aggressive malignancy.